Roles of long noncoding RNAs in hepatocellular carcinoma
Roles of long noncoding RNAs in hepatocellular carcinoma
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DOI：
10.1016/j.virusres.2016.06.008
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发表时间：
2016-09-02
期刊：
影响因子：
5
通讯作者：
Li, Ning
中科院分区：
文献类型：
--
作者：
Shi, Linxi;Peng, Fang;Li, Ning
肝细胞癌（HCC）是世界上最常见的癌症之一，具有高发病率和高致死率。乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染是HCC的主要危险因素。长链非编码rna （IncRNA）参与多种生物学过程，IncRNA的异常表达与包括HCC在内的许多人类疾病有关。尽管近年来有许多关于HCC的研究报道，并且IncRNAs在癌变中的作用也得到了重视，但关于IncRNAs在HBV/ hcv诱导的HCC中的作用的报道却很有限。在这篇综述中，我们将重点介绍incrna在HCC和HBV/ hcv相关HCC中的功能作用的最新进展。(C) 2016 Elsevier B.V.版权所有
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with high prevalence and lethality. Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infection are the major risk factors for HCC. Long noncoding RNAs (IncRNAs) are involved in diverse biological processes, and aberrant IncRNA expression is relevant to many human diseases including HCC. Although many researches on HCC have been reported and IncRNAs roles in carcinogenesis have been highlighted recently, reports on roles of IncRNAs in HBV/HCV-induced HCC are limited. In this review, we concentrate on recent progress regarding the functional roles of IncRNAs in HCC and HBV/HCV-related HCC. (C) 2016 Elsevier B.V. All rights reserved.