Feasibility of functional neuroimaging to understand adolescent women's sexual decision making.
Feasibility of functional neuroimaging to understand adolescent women's sexual decision making.
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DOI：
10.1016/j.jadohealth.2014.11.004
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发表时间：
2015-04
期刊：
影响因子：
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通讯作者：
Fortenberry JD
中科院分区：
文献类型：
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作者：
Hensel DJ;Hummer TA;Acrurio LR;James TW;Fortenberry JD
目的：对于年轻女性来说，青春期后新的性经历会正常增加，并且与控制风险行为自我调节的大脑区域的广泛变化相一致。这些神经发育的变化可能会使一些年轻女性容易产生负面的性后果，包括性传播感染和意外怀孕。我们评估了使用功能神经影像学来了解青春期女性性决策的可行性。方法：青少年女性（N = 14； 14 - 15岁）完成了入组访谈，一项测量食欲刺激的神经激活的神经成像任务，以及扫描后30天的前瞻性日记，描述日常情绪和性行为。描述性和推断性统计评估了影像学和行为数据之间的关联。结果年轻女性对神经影像学和日记治疗方案的依从性较高。认知-情感网络（包括前额叶和前扣带区）的神经活动在做出低风险决策时显著增强。与其他决定相比，高风险的性决定在前扣带引发了更大的活动，而低风险的性决定在视觉皮层区域引发了更大的活动。年轻女性的性决定评分与她们的性历史特征和每日自我报告的性情绪和性行为有关。结论招募并保留一组女性参与者，在不同假设性风险水平的基础上，执行一项功能磁共振成像任务，重点是做出关于性的决定，并在任务完成后完成纵向前瞻性日记，这是可行的。初步证据表明，风险水平对这些女性的性决策相关的大脑活动有不同的影响，这可能与过去和未来的性行为有关。
PurposeFor young women, new sexual experiences normatively increase after puberty and coincide with extensive changes to brain regions governing self-regulation of risk behavior. These neurodevelopmental changes could leave some young women vulnerable for negative sexual outcomes, including sexually transmitted infection and unintended pregnancy. We evaluated the feasibility of using functional neuroimaging to understand the sexual decision making of adolescent women.MethodsAdolescent women (N = 14; 14–15 years) completed enrollment interviews, a neuroimaging task gauging neural activation to appetitive stimuli, and 30 days of prospective diaries following the scan characterizing daily affect and sexual behaviors. Descriptive and inferential statistics assessed the association between imaging and behavioral data.ResultsYoung women were highly compliant with neuroimaging and diary protocol. Neural activity in a cognitive-affective network, including prefrontal and anterior cingulate regions, was significantly greater during low-risk decisions. Compared with other decisions, high-risk sexual decisions elicited greater activity in the anterior cingulate, and low-risk sexual decision elicited greater activity in regions of the visual cortex. Young women's sexual decision ratings were linked to their sexual history characteristics and daily self-reports of sexual emotions and behaviors.ConclusionsIt is feasible to recruit and retain a cohort of female participants to perform a functional magnetic resonance imaging task focused on making decisions about sex, on the basis of varying levels of hypothetical sexual risk, and to complete longitudinal prospective diaries following this task. Preliminary evidence suggests that risk level differentially impacts brain activity related to sexual decision making in these women, which may be related to past and future sexual behaviors.