Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail.
Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail.
复制标题
DOI：
10.1158/1940-6207.capr-09-0083
复制
发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Dong Z
中科院分区：
文献类型：
--
作者：
Bode AM;Dong Z
流行病学研究表明，绿色茶消费降低癌症风险（1-3）。这些数据得到了大量临床前研究结果的支持，这些研究表明，绿色和红茶是各种啮齿动物模型（4-6）中致癌作用的有效抑制剂，包括皮肤癌、肺癌、食道癌、胃癌、肝癌、十二指肠癌、小肠癌、胰腺癌、结直肠癌和乳腺癌模型不同的茶制剂含有不同量的多酚，并且表没食子儿茶素3-没食子酸酯（EGCG）是在茶中发现的最丰富、研究最充分并且可能最有效（抗癌）的多酚（4-6，12-15）。除了表没食子儿茶素没食子儿茶素，这可能占50%至80%的总抗氧化剂多酚称为儿茶素在茶（6，12-16），其他茶cate（-）下巴包括（-）-表没食子儿茶素，（-）-表儿茶素没食子酸酯，和（-）-表儿茶素。这些多酚可达到的组织浓度在低微摩尔范围内，因此，在体外观察到的高得多的浓度的抗癌作用可能与体内抗癌过程无关（4，5，17）。
Epidemiologic studies indicate that green tea consumption decreases cancer risk (1–3). These data are supported by the results of numerous preclinical studies, which have shown that green and black tea are potent inhibitors of carcinogenesis in various rodent models (4–6), including models for cancers of the skin, lung, esophagus, stomach, liver, duodenum, small intestine, pancreas, colon-rectum, and mammary gland (1, 4, 6–11).Different tea preparations contain varying amounts of polyphenols, and epigallocatechin 3-gallate (EGCG) is the most abundant, best-studied, and possibly most potent (against cancer) polyphenol found in tea (4–6, 12–15). Besides EGCG, which may account for 50% to 80% of the total antioxidant polyphenols called catechins in tea (6, 12–16), other tea cate (−) chins include (−)-epigallocatechin,(−)-epicatechin gallate, and (−)-epicatechin. The achievable tissue concentrations of these polyphenols are in the low micromolar range, and therefore, anticarcinogenic effects observed with much higher concentrations in vitro may not be relevant to the in vivo anticarcinogenic process (4, 5, 17).