Periodic benzodiazepine antagonist administration prevents benzodiazepine withdrawal symptoms in primates.
Periodic benzodiazepine antagonist administration prevents benzodiazepine withdrawal symptoms in primates.
复制标题
定期给予苯二氮卓类拮抗剂可预防灵长类动物的苯二氮卓类戒断症状。
DOI：
10.1016/0014-2999(86)90005-1
复制
发表时间：
1986
影响因子：
5
通讯作者：
Heninger,G
中科院分区：
文献类型：
--
作者：
Gallager,DW;Heninger,K;Heninger,G
恒河猴每天服用地西泮（1.5 或 6 毫克/公斤）会导致身体依赖性逐渐发展，Ro15-1788（5 毫克/公斤肌肉注射）会诱发戒断症状，包括干呕、呕吐、面部和四肢颤抖，这证明了这一点。在连续暴露地西泮的相似时期内，每三天施用一次苯二氮卓类拮抗剂 Ro15-1788，可显着减少戒断行为。在地西泮暴露过程中（有或没有定期 Ro15-1788 给药），长期地西泮对自发引发的镇静和主动行为的影响没有改变。据推测，每次接触苯二氮卓类拮抗剂后，身体依赖性都会恢复到药物初始状态。这种治疗可能代表一种可能的治疗方法，用于预防（时间依赖性）身体依赖性的发展以及伴随的严重戒断症状。
Daily administration of diazepam (1.5 or 6 mg/kg) in Rhesus monkeys results in the progressive development of physical dependence, as evidenced by Ro15-1788 (5 mg/kg i.m.) precipitated withdrawal symptoms including retching, vomiting, face and limb tremors. Every third day administration of the benzodiazepine antagonist, Ro15-1788, during a similar period of continuous diazepam exposure, significantly decreases withdrawal behaviors. During the course of diazepam exposure (with or without periodic Ro15-1788 administration) effects of chronic diazepam on spontaneously elicited sedative and active behaviors were not altered. It is postulated that physical dependence reverts to a drug naive state after each exposure to the benzodiazepine antagonist. This treatment may represent a possible therapeutic approach for preventing the (time dependent) development of physical dependence and the accompanying severe withdrawal symptoms.