Functional Transformation of Gastric Parietal Cells and Intracellular Trafficking of Ion Channels/Transporters in the Apical Canalicular Membrane Associated with Acid Secretion
Functional Transformation of Gastric Parietal Cells and Intracellular Trafficking of Ion Channels/Transporters in the Apical Canalicular Membrane Associated with Acid Secretion
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DOI：
10.1248/bpb.34.813
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发表时间：
2011-06-01
影响因子：
2
通讯作者：
Sawaguchi, Akira
中科院分区：
文献类型：
--
作者：
Aoyama, Fumiyo;Sawaguchi, Akira
胃腺壁细胞是一种高度分化的细胞，负责将胃酸分泌到胃腔中。为了响应酸分泌的刺激，壁细胞经历充分表征的形态学转变，以从细胞质小管囊泡向顶小管膜募集H+/K+-ATP酶。除了通过H+/K+-ATP酶的H+挤出外，还需要分别通过氯和钾通道/转运体的Cl-流出和K+再循环穿过顶小管膜。在过去的十年中，一些分子候选人的Cl-流出和K+回收已被确定在顶小管膜的壁细胞。本文综述了胃壁细胞的功能转化和与胃酸分泌相关的顶小管膜上表达的离子通道/转运蛋白的胞内转运。
The parietal cell of the gastric gland is a highly differentiated cell responsible for the gastric hydrochloric acid secretion into the lumen of the stomach. In response to stimulation of acid secretion, the parietal cells undergo well-characterized morphological transformations to recruit H+/K+-ATPase from the cytoplasmic tubulovesicles to the apical canalicular membrane. Besides H+ extrusion via H+/K+-ATPase, Cl- efflux and K+ recycling across the apical canalicular membrane are necessary via chloride and potassium channels/transporters, respectively. In the last decade, a number of molecular candidates for the Cl- efflux and K+ recycling have been identified in the apical canalicular membrane of the parietal cell. This review focuses on the functional transformation of gastric parietal cells and intracellular trafficking of ion channels/transporters expressed in the apical canalicular membrane associated with gastric acid secretion.