Silver-Zwitterion Organic-Inorganic Nanocomposite with Antimicrobial and Antiadhesive Capabilities
Silver-Zwitterion Organic-Inorganic Nanocomposite with Antimicrobial and Antiadhesive Capabilities
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DOI：
10.1021/la304708b
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发表时间：
2013-03-19
期刊：
影响因子：
3.9
通讯作者：
Zhang, Xiangwen
中科院分区：
文献类型：
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作者：
Hu, Rong;Li, Guozhu;Zhang, Xiangwen
在这项工作中，我们展示了一种方便，高效，环保的策略，实现抗菌和抗粘附的目的，使用银-两性纳米复合材料。纳米复合材料的合成依赖于负载两性离子聚合物刷与Ag+前体离子，然后通过紫外线（UV）照射原位还原为Ag纳米粒子。聚（磺基甜菜碱甲基丙烯酸酯）（pSBMA）和聚（羧基甜菜碱甲基丙烯酸酯）（pCBMA）已被研究作为基质包埋的银。将良好分散的银纳米颗粒嵌入pCBMA基质中。所获得的pCBMA-银杂合体（CB-Ag）能够在接触时杀死细菌并在潮湿条件下释放死细菌。结果表明，使用这种纳米复合材料系统作为一个强大的和可靠的抗微生物和防粘平台，防止微生物定植的可行性。
In this work, we demonstrate a convenient, efficient, and environmentally benign strategy to achieving antimicrobial and antiadhesive purposes using a silver-zwitterion nanocomposite. The synthesis of the nanocomposite relies on loading zwitterionic polymer brushes with Ag+ precursor ions, followed by their in situ reduction to Ag nanoparticle by ultraviolet (UV) irradiation. Both poly(sulfobetaine methacrylate) (pSBMA) and poly(carboxybetaine methacrylate) (pCBMA) have been studied as matrices for the embedding of silver. Well-dispersed silver nanoparticles are embedded into pCBMA matrices. The obtained pCBMA-silver hybrid (CB-Ag) is capable of killing bacteria upon contact and releasing dead bacteria under wet conditions. Results suggest the feasibility of using this nanocomposite system as a robust and reliable antimicrobial and antiadhesive platform for the prevention of microbial colonization.