Diastolic pressure ratio: new approach and validation vs. the instantaneous wave-free ratio
Diastolic pressure ratio: new approach and validation vs. the instantaneous wave-free ratio
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DOI：
10.1093/eurheartj/ehz230
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发表时间：
2019-08-14
影响因子：
39.3
通讯作者：
Oldroyd, Keith G.
中科院分区：
文献类型：
--
作者：
Johnson, Nils P.;Li, Wenguang;Oldroyd, Keith G.
目的：瞬时无波比率（iFR）和全周期Pd/Pa研究非充血性条件下的冠状动脉生理学。为了测试的无波期间的静息冠状动脉压力测量时，独特的生理特性，我们比较了事后的舒张压比（dPR）和Pd/Pa对iFR的数值相似性和测试/重测repetitive.Methods和结果八百九十三病变833名受试者包括从VERIFY 2和CRISST研究。将舒张压比和Pd/Pa的线性变换与iFR进行比较，以确定诊断性能。dPR和iFR之间的平均差异[Delta = -0.006 +/- 0.011，r（2）= 0.993，受试者工作特征（ROC）曲线下面积（AUC）= 0.997]反映了立即重复的两次iFR测量的差异（Delta = 0.001 +/-0.011，r（2）= 0.993，AUC = 0.997）。
Aims The instantaneous wave-free ratio (iFR) and whole-cycle Pd/Pa investigate coronary physiology during non-hyperaemic conditions. To test for unique physiologic properties of the wave-free period when making resting coronary pressure measurements, we compared post hoc a diastolic pressure ratio (dPR) and Pd/Pa against iFR for numerical similarity and test/retest repeatability.Methods and results Eight hundred and ninety-three lesions from 833 subjects were included from the VERIFY 2 and CONTRAST studies. Diastolic pressure ratio and a linear transform of Pd/Pa were compared against iFR for diagnostic performance. Mean difference between dPR and iFR [Delta = -0.006 +/- 0.011, r(2) = 0.993, area under receiver operating characteristic (ROC) curve (AUC) = 0.997] mirrored the difference of two iFR measurements repeated immediately (Delta =