At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
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DOI：
10.4161/cc.8.12.8810
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发表时间：
2009-06-15
期刊：
影响因子：
4.3
通讯作者：
Blagosklonny, Mikhail V.
中科院分区：
文献类型：
--
作者：
Demidenko, Zoya N.;Blagosklonny, Mikhail V.
在此我们证明，在细胞生长抑制的接近毒性的浓度下，白藜芦醇抑制S6磷酸化，并阻止人类细胞的衰老形态。通过一种灵敏的功能检测，我们发现白藜芦醇部分阻止了与细胞衰老相关的增殖潜能的丧失。白藜芦醇的效果不如雷帕霉素，因为白藜芦醇在高浓度下的毒性限制了其对衰老的抑制作用。我们探讨了抑制雷帕霉素靶蛋白（mTOR）并抑制细胞衰老的白藜芦醇浓度在临床上是否可实现，以及白藜芦醇对mTOR的部分抑制是否足以影响机体衰老。
Here we demonstrated that, at cytostatic, near-toxic concentrations, resveratrol inhibited S6 phosphorylation and prevented the senescence morphology in human cells. Using a sensitive functional assay, we found that resveratrol partially prevented loss of the proliferative potential associated with cellular senescence. Resveratrol was less effective than rapamycin, because aging-suppression by resveratrol was limited by its toxicity at high concentrations. We discuss whether concentrations of resveratrol that inhibit mTOR (target of rapamycin) and suppress cellular senescence are clinically achievable and whether partial inhibition of mTOR by resveratrol might be sufficient to affect organismal aging.