Exploring the Limit of Multiplexed Near-Field Optical Trapping
Exploring the Limit of Multiplexed Near-Field Optical Trapping
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DOI：
10.1021/acsphotonics.1c00354
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发表时间：
2021-07-06
期刊：
影响因子：
7
通讯作者：
Ciminelli, Caterina
中科院分区：
文献类型：
--
作者：
Conteduca, Donato;Brunetti, Giuseppe;Ciminelli, Caterina
光学捕捉通过使用光学力操纵细胞和单分子，彻底改变了我们对生物学的理解。向近场移动会产生强烈的磁场梯度，以捕获非常小的粒子，如DNA片段、病毒和囊泡。这种光学纳米铲子在生物医学应用中的下一个前沿是捕获多个粒子并研究它们的异质性。为此，我们研究了可以平行捕获多个粒子的介电超表面。我们已经探索了这种超表面的要求，并引入了一种结构，允许以非常低的总功率P<；26 mW捕获大量纳米粒子(>；1000)。我们通过实验演示了亚表面提供的近场增强，并对其捕获性能进行了模拟。我们优化了MetasSurface以捕获直径100 nm的颗粒，这将为病毒和细胞外小泡的新生物学研究打开机会，例如研究异质性，或大规模并行化分析以用于药物发现。
Optical trapping has revolutionized our understanding of biology by manipulating cells and single molecules using optical forces. Moving to the near-field creates intense field gradients to trap very smaller particles, such as DNA fragments, viruses, and vesicles. The next frontier for such optical nanotweezers in biomedical applications is to trap multiple particles and to study their heterogeneity. To this end, we have studied dielectric metasurfaces that allow the parallel trapping of multiple particles. We have explored the requirements for such metasurfaces and introduce a structure that allows the trapping of a large number of nanoscale particles (>1000) with a very low total power P < 26 mW. We experimentally demonstrate the near-field enhancement provided by the metasurface and simulate its trapping performance. We have optimized the metasurface for the trapping of 100 nm diameter particles, which will open up opportunities for new biological studies on viruses and extracellular vesicles, such as studying heterogeneity, or to massively parallelize analyses for drug discovery.