STRUCTURAL-PROPERTIES OF A SUBSET OF NEPHRITOGENIC ANTI-DNA ANTIBODIES
STRUCTURAL-PROPERTIES OF A SUBSET OF NEPHRITOGENIC ANTI-DNA ANTIBODIES
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DOI：
10.1007/bf02918278
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发表时间：
1994-01-01
影响因子：
4.4
通讯作者：
MADAIO, MP
中科院分区：
文献类型：
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作者：
KIEBEREMMONS, T;FOSTER, MH;MADAIO, MP
狼疮自身抗体的结构分析开始为抗原特异性和致病性的分子基础提供线索。本分析表明，多个轻链和重链含有可以促进DNA结合的残基，重申了不同氨基酸联合收割机形成对dsDNA和ssDNA具有亲和力的抗原结合口袋的多种方式。此外，这种分析表明，这些构象和接触残基是固有的种系序列，虽然氨基酸的变化在关键位置（体细胞引入）调节抗原结合，并出现影响的能力，个别免疫球蛋白形成免疫沉积物。需要对具有密切相关的V区序列和不同致病特性的其他单个免疫球蛋白进行分析，以解决特定基序对致病性的贡献。
Structural analysis of lupus autoantibodies is beginning to provide clues to the molecular basis for antigenic specificity and pathogenicity. The present analysis indicates that multiple light and heavy chains contain residues which can facilitate DNA binding, reaffirming the notion that there are multiple ways that different amino acids combine to form an antigen-binding pocket with affinity for dsDNA and ssDNA. Furthermore, this analysis suggests that these conformations and contact residues are intrinsic to germline sequences, although amino acid changes at critical locations (somatically introduced) modulate antigen binding, and appear to influence the capacity of individual immunoglobulin to form immune deposits. Analysis of additional individual immunoglobulins with closely related V-region sequences and differing pathogenic properties will be required to resolve the contribution of specific motifs to pathogenecity.