Risk factors associated with the occurrence of hip fracture in Japanese patients with rheumatoid arthritis: a prospective observational cohort study
Risk factors associated with the occurrence of hip fracture in Japanese patients with rheumatoid arthritis: a prospective observational cohort study
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DOI：
10.1007/s00198-012-2080-0
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发表时间：
2013-04-01
影响因子：
4
通讯作者：
Yamanaka, H.
中科院分区：
文献类型：
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作者：
Furuya, T.;Inoue, E.;Yamanaka, H.
在一项前瞻性的观察性队列研究中，评估了与日本类风湿性关节炎(RA)患者髋部骨折发生相关的危险因素。肢体残疾、高龄、全膝关节置换术(TKR)史、低体重指数(BMI)似乎与髋部骨折的发生有关。本研究旨在评估潜在危险因素与日本RA患者髋部骨折发生的相关性。自我报告的髋部骨折使用患者的医疗记录进行了核实。使用COX比例风险模型分析了各种危险因素对髋部骨折发生的独立贡献。在平均5.2年的随访期中，152名患者报告了152处髋部骨折。其中97例(男15例，女82例)97例髋部骨折均经病历证实。日本版健康评估问卷(J-HAQ)残疾评分[每1分，危险比(HR)，2.64；95%可信区间(CI)，1.94-3.58]、年龄(每10年；HR，1.53；95%CI，1.25-1.87)、TKR病史(HR，3.75；95%CI，1.57-8.96)和BMI(每1 kg/m(2)，HR，0.92；95%CI，0.86-0.99)与髋部骨折显著相关。在J-HAQ的8个领域中，J-HAQ(上升)(HR，1.74；95%CI，1.28-2.36)和J-HAQ(卫生)(HR，1.58；95%CI，1.11-2.24)与髋部骨折的发生显著相关。高J-HAQ残疾评分、高龄、TKR病史和低BMI似乎与日本RA患者髋部骨折的发生有关。在J-HAQ的八个领域中，起病和卫生障碍似乎与该患者群体中髋部骨折的发生有关。
Risk factors associated with the occurrence of hip fracture in Japanese patients with rheumatoid arthritis (RA) were evaluated in a prospective, observational cohort study. Physical disability, advanced age, history of total knee replacement (TKR), and low body mass index (BMI) appear to be associated with the occurrence of hip fracture.This study seeks to evaluate the association between potential risk factors and the occurrence of hip fractures in Japanese RA patients.A total of 9,720 patients (82.1 % female; mean age, 55.7 years) with RA were enrolled in a prospective observational study from 2000 to 2010. Self-reported hip fractures were verified using patient medical records. Cox proportional hazards models were used to analyze independent contributions of various risk factors to hip fracture occurrence.During a mean follow-up of 5.2 years, 152 patients reported 152 hip fractures. Among these patients, 97 hip fractures in 97 patients (15 males, 82 females) were verified with medical records. Japanese version of the Health Assessment Questionnaire (J-HAQ) disability score [per 1 score, hazard ratio (HR), 2.64; 95 % confidence interval (CI), 1.94-3.58], age (per 10 years; HR, 1.53; 95 % CI, 1.25-1.87), history of TKR (HR, 3.75; 95 % CI, 1.57-8.96), and BMI (per 1 kg/m(2), HR, 0.92; 95 % CI, 0.86-0.99) were significantly associated with hip fractures. Among the scores on the eight domains of the J-HAQ, J-HAQ (arising) (HR, 1.74; 95 % CI, 1.28-2.36) and J-HAQ (hygiene) (HR, 1.58; 95 % CI, 1.11-2.24) were significantly correlated with the occurrence of hip fracture.High J-HAQ disability score, advanced age, history of TKR, and low BMI appear to be associated with the occurrence of hip fractures in Japanese RA patients. Among the eight domains of the J-HAQ, arising and hygiene disabilities appear to be correlated with the occurrence of hip fractures in this patient population.