Genomic Variant in IL-37 Confers A Significant Risk of Coronary Artery Disease.
Genomic Variant in IL-37 Confers A Significant Risk of Coronary Artery Disease.
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IL-37 的基因组变异会带来患冠状动脉疾病的显着风险。
DOI：
10.1038/srep42175
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发表时间：
2017-02-09
影响因子：
4.6
通讯作者：
Wang QK
中科院分区：
文献类型：
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作者：
Yin D;Naji DH;Xia Y;Li S;Bai Y;Jiang G;Zhao Y;Wang X;Huang Y;Chen S;Fa J;Tan C;Zhou M;Zhou Y;Wang L;Liu Y;Chen F;Liu J;Chen Q;Tu X;Xu C;Wang QK
白细胞介素1家族在免疫和炎症反应中起重要作用。冠状动脉疾病（CAD）是一种慢性炎症性疾病。然而，IL-1家族的第七个成员IL-37与CAD之间的遗传关联尚不清楚。在这里，我们表明，在IL-37基因（rs3811047）的单核苷酸多态性赋予CAD的显着风险。我们在来自中国的2,501名患者和3,116名对照的两个独立人群中进行了rs3811047与CAD之间的关联分析。进行定量RT-PCR分析以确定IL-37表达水平是否受rs3811047的影响。我们发现rs3811047的次要等位基因A在两个独立的群体中在隐性模型下与CAD显著相关（在GeneID Northernern群体中Padj = 5.51 × 10−3/OR = 1.56，在GeneID Central群体中Padj = 1.23 × 10−3/OR = 1.45）。这种关联在合并人群中变得更加显著（Padj = 9.70 × 10−6/OR = 1.47）。此外，在年龄和性别匹配的CAD病例对照人群中，这种关联仍然显著。rs3811047的等位基因A与IL-37 mRNA表达水平降低显著相关（n = 168，P = 3.78 × 10−4）。提示IL 37是一个新的冠心病易感基因，为冠心病的防治提供了潜在的靶点。
The interleukin 1 family plays an important role in the immune and inflammatory responses. Coronary artery disease (CAD) is a chronic inflammatory disease. However, the genetic association between IL-37, the seventh member of the IL-1 family, and CAD is unknown. Here we show that a single nucleotide polymorphism in the IL-37 gene (rs3811047) confers a significant risk of CAD. We have performed an association analysis between rs3811047 and CAD in two independent populations with 2,501 patients and 3,116 controls from China. Quantitative RT-PCR analysis has been performed to determine if the IL-37 expression level is influenced by rs3811047. We show that the minor allele A of rs3811047 is significantly associated with CAD in two independent populations under a recessive model (Padj = 5.51 × 10−3/OR = 1.56 in the GeneID Northernern population and Padj = 1.23 × 10−3/OR = 1.45 in the GeneID Central population). The association became more significant in the combined population (Padj = 9.70 × 10−6/OR = 1.47). Moreover, the association remains significant in a CAD case control population matched for age and sex. Allele A of rs3811047 shows significant association with a decreased mRNA expression level of IL-37 (n = 168, P = 3.78 × 10−4). These data suggest that IL37 is a new susceptibility gene for CAD, which provides a potential target for the prevention and treatment of CAD.