SARS-CoV-2 viral load is associated with increased disease severity and mortality.
SARS-CoV-2 viral load is associated with increased disease severity and mortality.
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DOI：
10.1038/s41467-020-19057-5
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发表时间：
2020-10-30
影响因子：
16.6
通讯作者：
Massachusetts Consortium for Pathogen Readiness
中科院分区：
文献类型：
--
作者：
Fajnzylber J;Regan J;Coxen K;Corry H;Wong C;Rosenthal A;Worrall D;Giguel F;Piechocka-Trocha A;Atyeo C;Fischinger S;Chan A;Flaherty KT;Hall K;Dougan M;Ryan ET;Gillespie E;Chishti R;Li Y;Jilg N;Hanidziar D;Baron RM;Baden L;Tsibris AM;Armstrong KA;Kuritzkes DR;Alter G;Walker BD;Yu X;Li JZ;Massachusetts Consortium for Pathogen Readiness
在冠状病毒疾病2019年(新冠肺炎)中，SARS-CoV-2病毒载量和疾病进展风险之间的关系在很大程度上仍未确定。在这里，我们量化了来自新冠肺炎疾病严重程度不同范围的参与者的SARS-CoV-2病毒载量，包括需要住院的患者、轻度疾病的门诊患者和已消除感染的个人。我们检测了27%的住院患者和13%的确诊为新冠肺炎的门诊患者的SARS-CoV-2血浆RNA。在因新冠肺炎入院治疗的参与者中，我们报告了可检测到的SARS-CoV-2血浆病毒载量的较高流行率与呼吸道疾病严重程度更严重、绝对淋巴细胞计数较低以及包括C-反应蛋白和IL-6在内的炎症标志物增加相关。SARS-CoV-2病毒载量，特别是血浆病毒血症，与死亡风险增加有关。我们的数据显示，SARS-CoV-2病毒载量可能有助于新冠肺炎患者的风险分层，因此其在疾病发病机制中的作用有待进一步探讨。在这项研究中，马萨诸塞州病原体准备联合会(MassCPR)的研究人员评估了SARS-CoV-2病毒载量和新冠肺炎疾病严重程度的关系，并报告了可检测到的病毒RNA水平，特别是血浆中的病毒RNA水平，与呼吸系统疾病的严重程度、炎症标志物和预测的死亡风险相关。
The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 viral load from participants with a diverse range of COVID-19 disease severity, including those requiring hospitalization, outpatients with mild disease, and individuals with resolved infection. We detected SARS-CoV-2 plasma RNA in 27% of hospitalized participants, and 13% of outpatients diagnosed with COVID-19. Amongst the participants hospitalized with COVID-19, we report that a higher prevalence of detectable SARS-CoV-2 plasma viral load is associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6. SARS-CoV-2 viral loads, especially plasma viremia, are associated with increased risk of mortality. Our data show that SARS-CoV-2 viral loads may aid in the risk stratification of patients with COVID-19, and therefore its role in disease pathogenesis should be further explored. In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death.
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