Prevalence of postpartum depression and its association with Diabetes mellitus among mothers in Mbarara, southwestern Uganda.
Prevalence of postpartum depression and its association with Diabetes mellitus among mothers in Mbarara, southwestern Uganda.
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乌干达西南部姆巴拉拉母亲产后抑郁症的患病率及其与糖尿病的关系。
DOI：
10.1101/2023.10.23.23297392
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Rukundo,GodfreyZari
中科院分区：
文献类型：
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作者：
Atuhaire,Catherine;Taseera,Kabanda;Atukunda,EstherC;Atwine,Daniel;Matthews,LynnT;Rukundo,GodfreyZari
背景：产后抑郁症（PPD）是一个重大的健康挑战，具有潜在的破坏性孕产妇和身体健康的结果。糖尿病的发展被假设为产后PPD对母亲的潜在不良影响之一，但这种关联尚未得到充分研究。本研究旨在确定乌干达西南部姆巴拉拉地区母亲产后抑郁症的患病率及其与糖尿病的关系。方法对309名产后6周到6个月的母亲进行了设施横断面研究。采用按比例分层连续抽样，从两个卫生设施，姆巴拉拉地区转诊医院和Bwizibwera第四卫生中心的产后诊所招募母亲。PPD使用迷你国际神经精神访谈（MINI 7.0）进行诊断。2)精神疾病诊断与统计手册，第5版（DSM-5）。通过测量血红蛋白A1 c（HbA 1c）诊断糖尿病。采用Logistic回归分析母亲患PPD与糖尿病的关系。结果研究确定，姆巴拉拉产后6周至6个月母亲的PPD患病率为40.5%（95%CI：35.1-45.1%）。在产后6周到6个月的母亲中，产后抑郁症与糖尿病之间存在统计学显著相关性。产后6周至6个月内患糖尿病的几率是同期未患PPD母亲的3倍（aOR= 3.0，95%CI：1.62-5.74，p= 0.001）。结论与建议产后6周到6个月内的妇女发生糖尿病的危险性较高。需要进行研究，以确定是否有针对性的糖尿病筛查，预防干预和管理将有助于减轻负担。
Background:Postpartum Depression (PPD) is a major health challenge with potentially devastating maternal and physical health outcomes. Development of diabetes mellitus has been hypothesized as one the potential adverse effects of PPD among mothers in the postpartum period but this association has not been adequately studied. This study aimed at determining prevalence of postpartum depression and its association with diabetes mellitus among mothers in Mbarara District, southwestern Uganda. Methods This was a facility based cross sectional study of 309 mothers between 6th week to 6th month after childbirth. Using proportionate stratified consecutive sampling, mothers were enrolled from postnatal clinics of two health facilities, Mbarara Regional Referral Hospital and Bwizibwera Health center IV. PPD was diagnosed using the Mini-International Neuropsychiatric Interview (MINI 7.0. 2) for the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). Diabetes mellitus was diagnosed by measuring Hemoglobin A1c (HbA1c). Logistic regression was used to determine the association of PPD and diabetes mellitus among mothers. Results The study established that PPD prevalence among mothers of 6th weeks to 6th months postpartum period in Mbarara was 40.5%(95% CI: 35.1-45.1%). A statistically significant association between postpartum depression and diabetes mellitus in mothers between 6 weeks and 6 months postpartum was established. The prevalence of diabetes mellitus among mothers with PPD was 28% compared to 13.6% among mothers without PPD Mothers with PPD had 3 times higher odds of being newly diagnosed with diabetes between 6 weeks and 6 months postpartum as compared to those without PPD during the same period (aOR= 3.0, 95% CI: 1.62-5.74, p= 0.001). Conclusion and Recommendations Postpartum women within 6th weeks to 6th months have higher risks of developing diabetes mellitus. Research is needed to determine if targeted diabetes mellitus screening, prevention interventions and management will help reduce the burden.