Axonal projections from the parasubthalamic nucleus
Axonal projections from the parasubthalamic nucleus
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DOI：
10.1002/cne.11036
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发表时间：
2004-02-16
影响因子：
2.5
通讯作者：
Swanson, LW
中科院分区：
文献类型：
--
作者：
Goto, M;Swanson, LW
丘脑旁核（PSTN）是下丘脑外侧区的分化，其特征在于表达β-前速激肽原（β-PPT）mRNA的独特神经元群体。用PHAL顺行束追踪法对大鼠PSTN的轴突投射进行了分析。结果表明，该细胞群的特点是大量的投射到副交感神经节前神经元在脑干（特别是在流涎核和迷走神经背侧运动核）和部分的臂旁核和孤束核，中继内脏感觉和味觉信息。此外，PSTN投射到大脑半球的皮质部分（边缘下区、无颗粒岛区、梨状后过渡区和外侧内嗅区以及后基底外侧杏仁核）-直接和间接地通过涉及室旁核和背内侧核的丘脑反馈回路-以及大脑半球的核部分（中央杏仁核、纹状体基底、终纹床核的菱形核和无名质）。因此，PSTN被定位成直接影响例如在进食行为和心血管调节期间活跃的中央副交感神经控制网络的许多大脑半球和后脑成分。(C)2004 Wiley-Liss，Inc.
The parasubthalamic nucleus (PSTN) is a differentiation of the lateral hypothalamic area, characterized by a distinct population of neurons expressing beta-preprotachykinin (beta-PPT) mRNA. The axonal projections from the PSTN have been analyzed with the PHAL anterograde tract tracing method in rats. The results indicate that the cell group is distinguished by massive projections to parasympathetic preganglionic neurons in the brainstem (especially in the salivatory nuclei and dorsal motor nucleus of the vagus nerve) and to parts of the parabrachial nucleus and nucleus of the solitary tract that relay viscerosensory and gustatory information. In addition, the PSTN projects to cortical parts of the cerebral hemisphere (infralimbic, agranular insular, postpiriform transition and lateral entorhinal areas, and posterior basolateral amygdalar nucleus)-directly and also indirectly via thalamic feedback loops involving the paraventricular and mediodorsal nuclei-and to nuclear parts of the cerebral hemisphere (central amygdalar nucleus, striatal fundus, rhomboid nucleus of the bed nuclei of the stria terminalis, and substantia innominata). The PSTN is thus positioned to influence directly many cerebral hemisphere and hindbrain components of the central parasympathetic control network that is active, for example, during feeding behavior and cardiovascular regulation. (C) 2004 Wiley-Liss, Inc.