WOUND-HEALING ACTIVITY OF ASTRAGALI RADIX IN RATS
WOUND-HEALING ACTIVITY OF ASTRAGALI RADIX IN RATS
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DOI：
10.1358/mf.2009.31.2.1353846
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发表时间：
2009-03-01
影响因子：
--
通讯作者：
Hahm, D. -H.
中科院分区：
文献类型：
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作者：
Han, D. -O.;Lee, H. -J.;Hahm, D. -H.
抑制炎症反应、加速基底细胞生长和平衡合成细胞外基质（ECM）在开放性皮肤创伤的愈合中起重要作用。为评价黄芪（Astragalus membranaceus [菲施.]的根）对创伤愈合的作用，在麻醉下在大鼠的背侧上制作实验性开放伤口。将AR的沸水浸提液浸泡在亲水性泡沫敷料中，每天一次局部应用于伤口，连续71天。通过对宏观外观进行评分并测量开放性伤口的面积来评估愈合过程。还通过组织学观察研究了愈合皮肤区域的分子方面，表明肉芽组织的细胞密度和线性排列。与作为阳性对照的表皮生长因子相比，AR提取物通过抑制炎症和刺激伤口区域中的基底细胞生长而显著加速皮肤伤口愈合。AR提取物对基底细胞增殖和血管生成的促进在伤口愈合的早期阶段是显著的，导致伤口愈合过程的持续时间显著减少。结论：0301提取物具有促进皮肤创伤愈合的作用。
Inhibition of inflammatory responses, acceleration of basal cell growth and balanced synthesis of the extracellular matrix (ECM) ate important in the healing of open cutaneous Wounds. To evaluate the wound-healing effects of Astragali Radix (AR) (the root of Astragalus membranaceus [Fisch.]), experimental open wounds were made on the dorsal side of rats under anesthesia. Boiling water extracts of AR, soaked into a hydrophilic foam dressing, were topically applied to the wounds once a day for 71 consecutive days. The healing process was assessed by scoring macroscopic appearance and measuring the area of the open wounds. Molecular aspects of the healing skin area were also investigated via histological observation indicating cell density and linear alignment Of the granulation tissue. The AR extracts significantly accelerated cutaneous Wound healing by suppressing inflammation and stimulating basal cell growth in the wound area compared to epidermal growth factor as a positive control. Promotion of basal cell proliferation and angiogenesis by the AR extracts was remarkable in the early stages of wound healing, resulting in a significant reduction in the duration of the wound-healing process. We Conclude 0301 extracts of AR could be useful in enhancing cutaneous wound healing.