How tolerogenic dendritic cells induce regulatory T cells.
How tolerogenic dendritic cells induce regulatory T cells.
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DOI：
10.1016/b978-0-12-380995-7.00004-5
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发表时间：
2010
影响因子：
--
通讯作者：
von Andrian, Ulrich H.
中科院分区：
文献类型：
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作者：
Maldonado, Roberto A.;von Andrian, Ulrich H.
自从1973年由Steinman和Cohn发现以来，树突状细胞(DC)作为先天免疫和获得性免疫的重要调节因子越来越受到人们的重视。DC非常擅长获取、处理和呈递抗原给T细胞。它们还调整抗原呈递的背景(从而调整结果)，以响应过多的环境输入，这些输入表明病原体或组织损伤的发生。这些信号通常促进DC成熟，从而促进DC从外周组织迁移到次级淋巴器官和次级淋巴器官内，以及诱导和调节效应性T细胞反应的能力。相反，最近的观察表明，DC对于确保免疫和平也是至关重要的。事实上，DC不断地以一种促进耐受性的方式呈现无害的自我和非自我抗原，至少部分是通过控制调节性T细胞(Treg)。树突状细胞是一种特殊的T细胞，通过影响树突状细胞和效应细胞的各种机制发挥其免疫抑制功能。在这里，我们回顾了最近的进展，我们了解耐受树突状细胞和树突状细胞之间的关系。
Since their discovery by Steinman and Cohn in 1973, dendritic cells (DCs) have become increasingly recognized for their crucial role as regulators of innate and adaptive immunity. DCs are exquisitely adept at acquiring, processing and presenting antigens to T cells. They also adjust the context (and hence the outcome) of antigen presentation in response to a plethora of environmental inputs that signal the occurence of pathogens or tissue damage. Such signals generally boost DC maturation, which promotes their migration from peripheral tissues into and within secondary lymphoid organs and their capacity to induce and regulate effector T cell responses. Conversely, more recent observations indicate that DCs are also crucial to ensure immunological peace. Indeed, DCs constantly present innocuous self and non-self antigens in a fashion that promotes tolerance, at least in part, through the control of regulatory T cells (Tregs). Tregs are specialized T cells that exert their immuno-suppressive function through a variety of mechanisms affecting both DCs and effector cells. Here, we review recent advances in our understanding of the relationship between tolerogenic DCs and Tregs.