Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects.
Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects.
复制标题
肾上腺素能 α 2A 受体基因 (ADRA2A) 与正常受试者的烦躁、敌意、冲动和记忆测量之间的关联。
DOI：
10.1097/00041444-200010010-00007
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
MacMurray,J
中科院分区：
文献类型：
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作者：
Comings,DE;Johnson,JP;Gonzalez,NS;Huss,M;Saucier,G;McGue,M;MacMurray,J
去甲肾上腺素能系统与觉醒、警觉、易怒、敌意和记忆有关。这表明去甲肾上腺素能受体的遗传变异可能是这些行为的危险因素。为了验证这一假设，这些特征的措施和肾上腺素能2A受体基因（ADRA 2A）的遗传变异之间的潜在关联，使用一个共同的单核苷酸多态性（SNP）多态性的启动子区域，在两个独立的主题：大学生（学生组），和父母的双胞胎在明尼苏达州的双胞胎研究（双胞胎组）。在学生组中，基因型（11> 12> 22）与布朗ADD总分（BADD）、记忆力和易怒的BADD分项得分、巴斯-杜基敌意量表（BDHI）总分、间接敌意、易怒、消极和言语攻击的BDHI分项得分呈显著线性相关。所有BADD和BDHI子评分的多元方差分析（MANOVA）在P<= 0.009时具有显著性。对于双胞胎组，相同的基因型关联是显着的多维人格问卷（MPQ）冲动性得分，但不MPQ侵略或伤害回避得分。ADRA 2A基因可解释这些评分的1.8-8.3%的方差。
: The noradrenergic system has been implicated in arousal, vigilance, irritability hostility, and memory. This suggests the hypothesis that genetic variants at noradrenergic receptors may be risk factors of these behaviors. To test this hypothesis, the potential association between measures of these traits and genetic variation at the adrenergic2A receptor gene (ADRA2A), using a common single nucleotide polymorphism (SNP) polymorphism of the promoter region, were examined in two independent sets of subjects: university students (student group), and parents of twins in the Minnesota Twin Study (twin group). In the student group, there was a significant linear association by genotype (11> 12> 22) for the total Brown ADD score (BADD), and BADD subscores of memory and irritability, and with the total Buss-Durkee Hostility Inventory (BDHI) score and BDHI subscores of indirect hostility, irritability, negativity, and verbal aggression. A multiple analysis of variance (MANOVA) of all the BADD and BDHI subscores was significant at P<= 0.009. For the twin group, the same genotype associations were significant for the Multidimensional Personality Questionnaire (MPQ) impulsivity scores but not for the MPQ aggression or harm avoidance scores. The ADRA2A gene accounted for 1.8-8.3% of the variance of these scores.