Growth in paediatric Crohn's disease
Growth in paediatric Crohn's disease
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DOI：
10.1159/000064759
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Czernichow, P
中科院分区：
文献类型：
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作者：
Cezard, JP;Touati, G;Czernichow, P
Growth failure (GF) is one of the major complications affecting children with inflammatory bowel disease. The faltering is temporary in 40-50% of cases and prolonged in 10-20% in Crohn's disease (CD). Such failure is rare in children with ulcerative colitis (5%). This complication is often associated with retarded bone development and delayed onset of sexual maturation. The delayed linear growth has a variety of causes including insufficient intake due to anorexia and the inflammatory process with increased energy and protein expenditure. Other factors are increased intestinal loss, secondary hypopituitarism and treatment with steroids. Therapeutic strategies of CID in children have changed this last decade by introducing new therapeutic agents such as topic steroids, immunosuppressors, anti-TNF antibody and notably in children enteral nutrition which has shown its efficacy in inducing remissions of active CID, restoring nutritional status and stimulation of linear growth. The results of a recent prospective multicentric study over 2 years in 82 CID show that severe GF (-2 SD) is initially present in 15% (n = 12), among them 11 remain
