D-Amphetamine reinstates behavior previously maintained by food: importance of context.
D-Amphetamine reinstates behavior previously maintained by food: importance of context.
复制标题
D-安非他明恢复以前通过食物维持的行为：环境的重要性。
DOI：
10.1097/00008877-200411000-00007
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发表时间：
2004
影响因子：
1.6
通讯作者：
Shahan,TA
中科院分区：
文献类型：
--
作者：
Odum,AL;Shahan,TA
药物自我给药恢复程序提供了一个重要的复发动物模型。虽然这一程序被广泛使用，但对所涉及的基本过程的调查却很少。本实验通过检测D-苯丙胺对食物寻求的恢复来确定恢复的特异性。在训练过程中，24只老鼠按下杠杆获取食物。8只大鼠在治疗前接受3.0 mg/kg D-苯丙胺，治疗后接受生理盐水。8只大鼠在治疗前后接受生理盐水。最后8只大鼠在治疗前接受生理盐水，治疗后接受3.0 mg/kg D-苯丙胺。然后所有大鼠均经历盐水注射和灭绝。在恢复试验期间，所有大鼠均接受3.0 mg/kg D-苯丙胺。D-苯丙胺显着增加杠杆按下大鼠与先前暴露于安非他明作为食物的预测线索（会前）和大鼠没有先前暴露于安非他明。这种影响是更大的大鼠与会前接触安非他明比大鼠没有以前的曝光。大鼠暴露于安非他明，但不作为食物的预测线索（会议后）没有表现出显着的恢复杠杆按压。因此，安非他明的恢复作用并不局限于先前通过安非他明自我给药维持的行为。在复发的动物模型中，药物寻求的恢复可能部分归因于自我给药药物的区分性和直接影响。
The drug self-administration reinstatement procedure provides an important animal model of relapse. While the procedure is widely used, there has been little investigation of the basic processes involved. This experiment determined the specificity of reinstatement by examining reinstatement of food seeking by D-amphetamine. During training, 24 rats pressed levers for food. Eight rats received 3.0 mg/kg D-amphetamine before and saline after sessions. Eight rats received saline before and after sessions. The final eight rats received saline before and 3.0 mg/kg D-amphetamine after sessions. All rats then experienced saline injections and extinction. During a reinstatement test, all rats received 3.0 mg/kg D-amphetamine. D-Amphetamine significantly increased lever pressing for rats with prior exposure to amphetamine as a predictive cue for food (pre-session) and for rats with no prior exposure to amphetamine. The effect was larger for rats with pre-session exposure to amphetamine than for rats with no previous exposure. Rats with exposure to amphetamine but not as a predictive cue for food (after sessions) did not show significant reinstatement of lever pressing. Therefore, the reinstating effects of amphetamine are not restricted to behavior previously maintained by amphetamine self-administration. In animal models of relapse, reinstatement of drug seeking could be due, in part, to discriminative and direct effects of self-administered drug.