Impaired fear conditioning following unilateral temporal lobectomy in humans
Impaired fear conditioning following unilateral temporal lobectomy in humans
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DOI：
10.1523/jneurosci.15-10-06846.1995
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发表时间：
1995-10
影响因子：
3.9
通讯作者：
K. LaBar;Joseph E LeDoux;D. Spencer;E. Phelps
中科院分区：
文献类型：
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作者：
K. LaBar;Joseph E LeDoux;D. Spencer;E. Phelps
经典的恐惧条件反射被用于在本研究中作为一个模型，调查人类受试者的内侧颞叶病变的情绪学习和记忆。动物研究已经揭示了内侧颞叶结构，特别是杏仁核，在简单和复杂的联想情绪反应中的关键作用。这些结构是否在人类中执行类似的功能尚不清楚。在简单和条件的歧视任务，单侧颞叶切除术的受试者表现出受损的条件反应收购相对于对照组。这种损害不能占赤字的非联想感觉或自主性能因素，或陈述性记忆的实验参数的差异。这些结果表明，人类的颞叶结构和其他哺乳动物一样，是情绪记忆网络的重要组成部分。
Classical fear conditioning was used in the present study as a model for investigating emotional learning and memory in human subjects with lesions to the medial temporal lobe. Animal studies have revealed a critical role for medial temporal lobe structures, particularly the amygdala, in simple and complex associative emotional responding. Whether these structures perform similar functions in humans is unknown. On both simple and conditional discrimination tasks, unilateral temporal lobectomy subjects showed impaired conditioned response acquisition relative to control subjects. This impairment could not be accounted for by deficits in nonassociative sensory or autonomic performance factors, or by differences in declarative memory for the experimental parameters. These results show that temporal lobe structures in humans, as in other mammals, are important components in an emotional memory network.