IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination
IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination
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DOI：
10.1016/j.jneuroim.2005.11.016
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发表时间：
2006-04-01
影响因子：
3.3
通讯作者：
Segal, BM
中科院分区：
文献类型：
--
作者：
Deshpande, P;King, IL;Segal, BM
实验性自身免疫性脑脊髓炎（EAE）是一种中枢神经系统炎性脱髓鞘疾病。IL-12 p40细胞因子在EAE诱导的CD 4 +T细胞的产生中起关键作用。在这里，我们表明，IL-12直接上调表达的粘附分子，P-选择素糖蛋白配体（PSGL-1），在B10. PL MBP-TCR转基因T细胞在其最初遇到抗原。IL-12刺激的髓磷脂反应性CD 4 +T细胞与PSGL-1阻断抗体的预孵育降低了EAE的发生率和严重程度。我们的结论是，IL-12驱动的PSGL-1表达可以促进自身免疫性脱髓鞘的发展。(c)2005 Elsevier B. V.保留所有权利。
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system. IL-12p40 rrionokines play a critical role in the generation of EAE-inducing CD4+T cells. Here we show that IL-12 directly upregulates the expression of the adhesion molecule, P-selectin glycoprotein ligand (PSGL-1), on B10.PL MBP-TCR transgenic T cells during their initial encounter with antigen. Pre-incubation of IL-12-stimulated myelin-reactive CD4+T cells with a blocking antibody against PSGL-1 reduced the incidence and severity of EAE. We conclude that IL-12-driven PSGL-1 expression can facilitate the development of autoimmune demyelination. (c) 2005 Elsevier B.V. All rights reserved.