Enhancement of radiosensitivity of skin of patients by high pressure oxygen.
Enhancement of radiosensitivity of skin of patients by high pressure oxygen.
复制标题
高压氧增强患者皮肤放射敏感性。
DOI：
10.1259/0007-1285-38-455-857
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发表时间：
1965
期刊：
影响因子：
--
通讯作者：
M. Papworth
中科院分区：
文献类型：
--
作者：
H. V. D. van den Brenk;R. Kerr;W. Richter;M. Papworth
本文报道了一项临床实验的结果，该实验旨在评价暴露于四个绝对大气压氧气中的麻醉患者皮肤的放射敏感性，相对于在环境条件下呼吸空气的相同患者皮肤的放射敏感性。将250- 1，250拉德范围内的90 Sr β辐射的单次辐射剂量输送到大腿前部皮肤的8个直径为1.2 cm的圆形区域。在所有剂量水平下，HPO中产生的皮肤损伤均增加。分别对空气和HPO中的皮肤损伤进行定量分析，结果估计，空气中给予的x rads对皮肤的损伤与HPO中给予的0.75 x rads对皮肤的损伤相同，单次剂量范围为250-750 rads。在剂量> 750拉德时，在HPO中照射的人皮肤相对于在空气中照射的皮肤显示出进一步的放射敏感性的进行性增加。这些结果进行了讨论，在以前报道的实验工作，并在其辐射的影响。
The results are reported of a clinical experiment designed to evaluate the radiosensitivity of skin of anaesthetised patients exposed to four atmospheres absolute of oxygen, relative to that of skin in the same patients breathing air under ambient conditions. Single radiation doses over the range 250–1,250 rads of 90Sr β radiation were delivered to eight 1·2 cm diameter circular areas of anterior thigh skin. Skin damage produced in HPO was increased at all dose levels. A quantitative analysis of the skin damage in air and HPO respectively resulted in an estimate that x rads administered in air produced the same damage to skin as 0·75 x rads administered in HPO for single doses in the range 250–750 rads. At doses > 750 rads human skin irradiated in HPO showed further progressive increase in radiosensitivity relative to that in air. These results are discussed in terms of previously reported experimental work and in respect to their radiotherapeutic implications.