Replication analysis of genetic variants on 17q11.2 and 9p21.2 with sporadic amyotrophic lateral sclerosis and Parkinson's disease in a Chinese population
Replication analysis of genetic variants on 17q11.2 and 9p21.2 with sporadic amyotrophic lateral sclerosis and Parkinson's disease in a Chinese population
复制标题
中国人群散发性肌萎缩侧索硬化症和帕金森病 17q11.2 和 9p21.2 基因变异的复制分析。
DOI：
10.1016/j.neurobiolaging.2015.07.026
复制
发表时间：
2015-11-01
影响因子：
4.2
通讯作者：
Shang, Hui-Fang
中科院分区：
文献类型：
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作者：
Chen, Xueping;Chen, Yongping;Shang, Hui-Fang
我们对中国人群中散发性肌萎缩侧索硬化（ALS）和帕金森病患者的2种遗传变异（17q11.2上的rs34517613和9p21.2上的rs3849942）进行了复制研究。通过全基因组关联研究，这2种变异被鉴定为与欧洲血统人群中ALS风险增加相关。在中国人群中，rs34517613和rs3849942均未显示相关性。这些位点不是中国西部汉族人群中散发性ALS和帕金森病的危险因素。(C)2015 Elsevier Inc. All rights reserved.
We performed a replication study of the 2 genetic variants, rs34517613 on 17q11.2 and rs3849942 on 9p21.2 in patients with sporadic amyotrophic lateral sclerosis (ALS) and Parkinson's disease in a Chinese population. These 2 variants are identified to be associated with increased risk of ALS in European-descended populations by genome-wide association studies. Both rs34517613 and rs3849942 showed no evidence of association in Chinese. These loci are not risk factors for sporadic ALS and Parkinson's disease in the western Han Chinese population. (C) 2015 Elsevier Inc. All rights reserved.