Improvement of cardiac function after immunoadsorption in patients with dilated cardiomyopathy
Improvement of cardiac function after immunoadsorption in patients with dilated cardiomyopathy
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DOI：
10.3109/08916930109007387
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发表时间：
2001-01-01
期刊：
影响因子：
3.5
通讯作者：
Friedrich, GB
中科院分区：
文献类型：
--
作者：
Felix, SB;Staudt, A;Friedrich, GB
扩张型心肌病（DCM）是一种以心肌收缩功能进行性抑制和心室扩张为特征的心肌疾病。心肌炎和扩张型心肌病患者存在细胞和体液免疫系统异常。在患有 DCM 的患者中已检测到多种循环心脏自身抗体。心脏抗体对 DCM 心脏功能障碍的相对影响仍有待阐明。通过免疫吸附提取抗体已成功用于治疗各种自身免疫性疾病。在这篇综述中，我们报告了最近的研究，这些研究表明免疫吸附可以改善 DCM 患者的心脏功能。这些研究的数据表明，体液免疫系统的激活以及心脏自身抗体的产生可能在 DCM 患者的心脏功能障碍中发挥功能性作用。
Dilated cardiomyopathy (DCM) is a myocardial disease characterized by progressive depression of myocardial contractile function and by ventricular dilatation. Abnormalities of the cellular and humoral immune system are present in patients with myocarditis and DCM. Various circulating cardiac autoantibodies have been detected among patients suffering from DCM. The relative contribution of cardiac antibodies to cardiac malfunction in DCM remains to be elucidated. Extraction of antibodies by immunoadsorption has been successfully used for treatment of various autoimmune diseases. In this review we report recent studies, which indicate that immunoadsorption improves cardiac function of patients with DCM. The data from these studies indicate that activation of the humoral immune system, with production of cardiac autoantibodies, may play a functional role in cardiac malfunction of patients with DCM.