Double Dissociation of Stimulus-Value and Action-Value Learning in Humans with Orbitofrontal or Anterior Cingulate Cortex Damage
Double Dissociation of Stimulus-Value and Action-Value Learning in Humans with Orbitofrontal or Anterior Cingulate Cortex Damage
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DOI：
10.1523/jneurosci.3164-11.2011
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发表时间：
2011-10-19
影响因子：
5.3
通讯作者：
Fellows, Lesley K.
中科院分区：
文献类型：
--
作者：
Camille, Nathalie;Tsuchida, Ami;Fellows, Lesley K.
适应性决策涉及选择最有价值的选项，通常是通过采取行动。这种选择需要价值比较，但关于这些比较是否发生在刺激（基于商品）价值、基于行动的价值或两者的层面上存在争议。一种观点认为，价值过程是连续发生的，刺激价值通知行动价值。然而，对非人类灵长类动物的损伤研究表明，这两种选择是分离的。在这里，我们研究了患有局灶性额叶损伤的人类的行动价值和刺激价值学习。眶额损伤破坏了在正反馈后维持正确刺激选择的能力，但不破坏行动的能力，而以背侧前扣带皮层为中心的损伤则导致相反的缺陷。这些发现认为，存在不同的、特定领域的机制，通过这些机制应用结果价值来指导后续决策，具体取决于选择是在刺激之间还是在行动之间。
Adaptive decision making involves selecting the most valuable option, typically by taking an action. Such choices require value comparisons, but there is debate about whether these comparisons occur at the level of stimuli (goods-based) value, action-based value, or both. One view is that value processes occur in series, with stimulus value informing action value. However, lesion work in nonhuman primates suggests that these two kinds of choice are dissociable. Here, we examined action-value and stimulus-value learning in humans with focal frontal lobe damage. Orbitofrontal damage disrupted the ability to sustain the correct choice of stimulus, but not of action, after positive feedback, while damage centered on dorsal anterior cingulate cortex led to the opposite deficit. These findings argue that there are distinct, domain-specific mechanisms by which outcome value is applied to guide subsequent decisions, depending on whether the choice is between stimuli or between actions.