Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men
Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men
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DOI：
10.1161/strokeaha.119.025964
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发表时间：
2019-10-01
期刊：
影响因子：
8.3
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
--
作者：
Shitara, Satoshi;Fujiyoshi, Akira;Ueshima, Hirotsugu
背景和目的：很少有基于社区的研究报道用磁共振血管造影术评估颅内动脉狭窄（ICAS）的患病率。目的是通过磁共振血管造影术确定日本男性普通人群中ICAS的患病率，并调查ICAS与传统心血管危险因素之间的相关性。方法-滋贺亚临床动脉粥样硬化流行病学研究随机招募并检查了2006年至2008年来自日本滋贺草津市的参与者（基线）; 740名男性返回进行随访，并在2012年至2015年接受了1.5 T脑磁共振血管造影术。参与者被分类为在任何检查的动脉中具有无ICAS、轻度ICAS（1至= 50%）。在排除了有中风史的男性后，使用多变量logistic回归分析709名男性，以评估传统心血管危险因素与非ICAS组的独立关联。轻度和重度ICAS的年龄标准化患病率分别为20.7%和4.5%（以2010年日本人口动态统计数据为参考）。年龄，高血压，糖尿病和血脂异常与一个更高的患病率严重ICAS后，同时调整传统的心血管风险factors.Conclusions-In一个社区为基础的样本的日本男性，ICAS估计是存在于25.2%，代谢危险因素，除了高血压和年龄。这些结果支持了综合管理传统心血管危险因素对预防卒中的重要性。
Background and Purpose-Few community-based studies have reported the prevalence of intracranial artery stenosis (ICAS) assessed with magnetic resonance angiography. The aim was to determine the prevalence of ICAS using magnetic resonance angiography in a general population of Japanese men and to investigate the associations between ICAS and conventional cardiovascular risk factors.Methods- The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited and examined participants from Kusatsu City, Shiga, Japan, in 2006 to 2008 (baseline); 740 men returned for follow-up and underwent 1.5 T brain magnetic resonance angiography in 2012 to 2015. Participants were categorized as having no-ICAS, mild-ICAS (1 to = 50%) in any of the arteries examined. After excluding the men with a history of stroke, 709 men were analyzed using multivariable logistic regression to assess independent associations of conventional cardiovascular risk factors with reference to the no-ICAS group.Results-The participants' mean age was 68.0 years. The age-standardized prevalences of mild and severe-ICAS were 20.7% and 4.5%, respectively (with the population of the 2010 Japanese vital statistics as the reference). Age, hypertension, diabetes mellitus, and dyslipidemia were associated with a higher prevalence of severe-ICAS after simultaneous adjustment for conventional cardiovascular risk factors.Conclusions-In a community-based sample of Japanese men, ICAS was estimated to be present in 25.2%, and related to metabolic risk factors, in addition to hypertension and age. These results support the importance of comprehensive management of conventional cardiovascular risk factors for stroke prevention.