Severe reduction of rat defensive behavior to a predator by discrete hypothalamic chemical lesions
Severe reduction of rat defensive behavior to a predator by discrete hypothalamic chemical lesions
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DOI：
10.1016/s0361-9230(97)00141-x
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发表时间：
1997-01-01
影响因子：
3.8
通讯作者：
Swanson, LW
中科院分区：
文献类型：
--
作者：
Canteras, NS;Chiavegatto, S;Swanson, LW
非特异性损伤和刺激方法表明，下丘脑对防御行为的表达至关重要，尽管调节这种行为的神经回路的组织尚不清楚。在大鼠下丘脑，我们发现，在呈现刺激(捕食者)后，Fos水平的增加仅限于特定的细胞组，已知的刺激(捕食者)可部分引发先天防御反应。乳头体前核背侧核Fos水平升高最为显著，其中的细胞体特异性化学损伤几乎消除了防御行为的两个主要成分，但增加了探索性行为，这表明下丘脑尾侧核在行为反应的表达中发挥关键作用，有时行为反应对个体的生存至关重要。我们之前已经证明，下丘脑内侧的Fos反应细胞群在一个神经系统中相互连接，与那些调节生殖和摄食行为的神经系统不同。(C)1997年爱思唯尔科学公司。
Nonspecific lesion and stimulation methods have suggested that the hypothalamus is critical for the expression of defensive behavior, although the organization of neural circuits mediating such behavior is unclear. In the rat hypothalamus, we found that increased Fos levels were restricted to specific cell groups following presentation of a stimulus (predator) known to elicit partly innate defensive responses. The dorsal premammillary nucleus showed the most striking increase in Fos levels, and cell body-specific chemical lesions therein virtually eliminated two major components of defensive behavior but increased exploratory behavior, suggesting that this caudal hypothalamic nucleus plays a critical role in the expression of behavioral responses sometimes critical for survival of the individual. We have previously shown that the Fos-responsive cell groups in the medial hypothalamus are interconnected in a neural system distinct from those mediating reproductive and ingestive behaviors. (C) 1997 Elsevier Science Inc.