Is there more to enamel matrix proteins than biomineralization?
Is there more to enamel matrix proteins than biomineralization?
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DOI：
10.1016/s0945-053x(01)00155-x
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发表时间：
2001-09
期刊：
影响因子：
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通讯作者：
M. Zeichner‐David
中科院分区：
文献类型：
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作者：
M. Zeichner‐David
釉蛋白是由成釉细胞合成的蛋白质。这些蛋白质被分泌到釉质细胞外基质中，在那里它们成核并调节羟基磷灰石晶体的生长以形成覆盖牙冠的矿化釉质。虽然这些蛋白质在釉质矿化中的确切作用刚刚开始被阐明，但新的研究表明，这些蛋白质可能在釉质形成之外具有功能。此外，牙釉质蛋白提取物目前被用于再生被牙周病破坏的牙周组织，新的研究表明，它们可能具有成软骨和成骨特性。这些新功能的釉蛋白将是本文的重点。
Enamel proteins are proteins synthesized by ameloblast cells. These proteins are secreted into the enamel extracellular matrix where they nucleate and regulate the growth of hydroxyapatite crystals to form the mineralized enamel covering the crown of the teeth. Although the exact role of these proteins in enamel mineralization is just beginning to be elucidated, new studies suggest that these proteins might have functions outside enamel formation. Furthermore, extracts of enamel proteins are currently being used to regenerate periodontal tissues destroyed by periodontal disease and new studies suggest that they might have chondrogenic and osteogenic properties. These new functions of enamel proteins will be the focus of this review.