Morphobiochemical analysis of calcified chondroblastic osteosarcoma of the mandible.
Morphobiochemical analysis of calcified chondroblastic osteosarcoma of the mandible.
复制标题
下颌骨钙化成软骨细胞骨肉瘤的形态生化分析。
DOI：
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
M. Nagumo
中科院分区：
文献类型：
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作者：
T. Tokuoka;S. Kakuta;K. Yagami;M. Nagumo
骨肉瘤的形态学特征已被广泛研究，但其生物化学方面的研究却很少。在这项研究中，从人钙化软骨母细胞骨肉瘤中获得的材料通过微量分析技术进行分析，揭示了同一组织部位的形态和生化特征。形态学上，表面肿瘤细胞呈非典型和有丝分裂象。在钙化区附近出现增生性软骨细胞，其密度增加。钙化区几乎所有细胞都呈增生性。生化分析表明，碱性磷酸酶活性急剧升高，无机磷酸盐向钙化区逐渐增加。钙化区的扩散与肿瘤中酸溶性磷酸盐和钙的含量一致。这些结果与骨骺生长软骨软骨内钙化的结果相似。
Although the morphological features of osteosarcoma have been widely investigated, there is little information about its biochemistry. In this study, materials obtained from human calcified chondroblastic osteosarcoma were analyzed by microanalytical techniques revealing both morphological and biochemical characteristics at the same tissue site. Morphologically, tumor cells in the surface area showed atypical and mitotic figures. Hypertrophic chondroblastic cells appeared and increased in density closer to the calcified region. Almost all cells in the calcified region were hypertrophic. Biochemical analysis revealed that alkaline phosphatase activity was steeply elevated and inorganic phosphate gradually increased towards the calcified region. The spread of the calcified region was coincident with the contents of acid-soluble phosphate and calcium of the tumor. These results were similar to those found in endochondral calcification of epiphyseal growth cartilage.
DOI：
10.1016/s0021-9258(18)33299-x
发表时间：
1983-01
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Ellis E. GolubS;Susan C. Schattschneider;Peter Berthold;A.G. Burke;Irving;Shapiro
通讯作者：
Ellis E. GolubS;Susan C. Schattschneider;Peter Berthold;A.G. Burke;Irving;Shapiro
生理pH下骨骺软骨膜碱性磷酸酶活性及其抑制剂的影响。
DOI：
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发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Cyboron,GW;Vejins,MS;Wuthier,RE
通讯作者：
Wuthier,RE