End tidal CO2 is an independent determinant of systolic blood pressure in women
End tidal CO2 is an independent determinant of systolic blood pressure in women
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DOI：
10.1097/00004872-199917080-00005
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发表时间：
1999-08-01
影响因子：
4.9
通讯作者：
Scuteri, A
中科院分区：
文献类型：
--
作者：
Anderson, DE;Parsons, DJ;Scuteri, A
目的近年来研究表明，高静息呼气末二氧化碳（PECO2）是正常血压人群血压对高钠摄入敏感性的一个标志。本研究调查了巴尔的摩老龄化纵向研究（BLSA）中314名健康受试者（153名男性和161名女性，年龄21 - 79岁）的静息PECO2与静息血压的关系。通过多元回归分析PECO2和其他变量与收缩压（SBP）和舒张压（DBP）的独立相关性。PECO2的年龄相关性变化的性别差异以及肺活量在PECO2-血压关系中的作用也进行了研究。结果静息PECO2是女性SEP的独立预测因子（β = 0.215; P <0.0015;总体r（2）= 0.27; P <0.0001），并解释了50岁以上女性SEP变异的10%以上。没有观察到PECO2与男性SEP或与男性或女性DBP的相关性，年轻女性的PECO2较低（36.0 +/-0.9 mmHg）比年轻男性（40.4 +/-2.0），但老年妇女更高结论PECO2是女性静息SEP的独立决定因素，尤其是50岁以上的女性。静息状态下PECO2个体差异的起源及其在慢性高血压发展中可能的作用仍有待澄清。J Hypertens 1999，17：1073 - 1080（C）Lippincott威廉姆斯& Wilkins.
Objective Recent studies have shown that high resting end tidal CO2 (PECO2) is a marker for blood pressure sensitivity to high sodium intake by normotensive humans. The present study investigated the association of resting PECO2 with resting blood pressure in participants in the Baltimore Longitudinal Study on Aging (BLSA).Design PECO2 of 314 healthy participants (153 men and 161 women, aged 21 -79 years) was measured by a respiratory gas monitor during 25 min of seated rest, and blood pressure every 5 min by an automated oscillometric system. The independent associations of PECO2 and other variables with systolic (SBP) and diastolic (DBP) blood pressure were analysed via multiple regression. Sex differences in age-associated changes in PECO2 and in the role of pulmonary capacity in the PECO2 - blood pressure relationships were also studied.Results Resting PECO2 was an independent predictor of SEP in women (beta = 0.215; P < 0.0015; overall r(2) = 0.27; P < 0.0001), and accounted for more than 10% of the variance in SEP in women over age 50 years. No such associations of PECO2 with SEP of men, or with DBP of men or women, were observed, PECO2 was lower in younger women (36.0 +/- 0.9 mmHg) than in younger men (40.4 +/- 2.0), but higher in older women (37.1 +/- 0.5) than in older men (35.5 +/- 0.4).Conclusions PECO2 is an independent determinant of resting SEP in women, especially those aged 50 years or more. The origin of individual differences in resting PECO2 and its possible role in the development of chronic hypertension remain to be clarified. J Hypertens 1999, 17:1073-1080 (C) Lippincott Williams & Wilkins.