Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study
Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study
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DOI：
10.1038/s41598-020-65989-9
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发表时间：
2020-06-09
影响因子：
4.6
通讯作者：
Kos, Mitja
中科院分区：
文献类型：
--
作者：
Cebron Lipovec, Nanca;Jazbar, Janja;Kos, Mitja
抗胆碱能负荷已在具有特定条件的特定患者群体中进行了广泛研究。然而，人们对普通人群的患病率知之甚少。这项回顾性横断面研究是对抗胆碱能药物门诊处方的全国数据库分析。该研究基于斯洛文尼亚 2018 年所有门诊处方的健康声明数据。使用抗胆碱能认知负担量表评估抗胆碱能负担。分析了三个年龄组：儿童（= 65 岁）。 29.8% 的参与者服用了抗胆碱能药物； 7.6% 的人面临临床上显着的抗胆碱能负担。暴露于抗胆碱能负担的患者比例最高的是老年人（43.2%），其次是成人（25.8%）和儿童（20.7%）。最常开出的具有最高抗胆碱能活性的药物是抗精神病药物和泌尿系统疾病药物（分别为 42.8% 和 40.2%）。活性第二高的药物主要是抗癫痫药（87.3%）。可能具有抗胆碱能活性的药物包括不同的治疗组。老年人的抗胆碱能负担最高，但成人和儿童的抗胆碱能负担也相当大。具有抗胆碱能活性的药物属于不同的治疗组。需要进一步研究这些药物在所有年龄段的安全使用。
Anticholinergic burden has been widely studied in specific patient populations with specific conditions. However, the prevalence in the general population is poorly understood. This retrospective cross-sectional study was a nationwide database analysis of outpatient prescriptions of anticholinergic medications. The study was based on Slovenian health claims data of all outpatient prescriptions in 2018. Anticholinergic burden was evaluated using the Anticholinergic Cognitive Burden scale. Three age groups were analysed: children (= 65 years). Anticholinergic medications were prescribed to 29.8% of the participants; 7.6% were exposed to a clinically significant anticholinergic burden. The proportion of patients exposed to anticholinergic burden was highest in older adults (43.2%), followed by adults (25.8%) and children (20.7%). The most frequently prescribed medications with the highest anticholinergic activity were antipsychotics and medications for urinary diseases (42.8% and 40.2%, respectively). Medications with second highest activity were mostly antiepileptics (87.3%). Medications with possible anticholinergic activity included diverse therapeutic groups. Anticholinergic burden is highest in older adults but is also considerable among adults and children. Medications with anticholinergic activity belong to diverse therapeutic groups. Further research is needed on safe use of these medications in all age groups.