Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies.
Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies.
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用于双模式癌症成像和图像引导化疗热疗的混合各向异性纳米结构
DOI：
10.1016/j.biomaterials.2016.06.063
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发表时间：
2016-10
期刊：
影响因子：
14
通讯作者：
Cheng Z
中科院分区：
文献类型：
--
作者：
Zhang R;Cheng K;Antaris AL;Ma X;Yang M;Ramakrishnan S;Liu G;Lu A;Dai H;Tian M;Cheng Z
多模态治疗诊断系统可以将两种或两种以上不同的治疗模式和多模态成像剂整合到一个纳米实体中，显示出巨大的癌症治疗前景。在此，我们开发了一种有效的和新颖的策略来合成具有固有的多模态治疗诊断能力[化疗，光热治疗，磁共振成像（MRI）和光声成像（派）]的混合各向异性纳米颗粒（HAN）。首次在MRI和派的指导下，将多功能混合纳米探针诱导的化疗和热疗同时应用于体内结肠癌荷瘤小鼠的治疗。
The multimodality theranostic system, which can integrate two or more different therapeutic modalities and multimodal imaging agents into a nanoentity, shows great promising prospects for the cancer treatment. Herein, we developed an efficient and novel strategy to synthesize hybrid anisotropic nanoparticles (HANs) with intrinsic multimodal theranostic capability [chemotherapy, photothermal therapy, magnetic resonance imaging (MRI), and photoacoustic imaging (PAI)]. For the first time, under the guidance of MRI and PAI, the chemotherapy and thermotherapy induced by administration of multifunctional hybrid nanoprobes were applied simultaneously to the treatment of colon cancer-bearing mice in vivo.