Comparison of acute phase protein and hemodynamic variables in dogs undergoing video-assisted thoracoscopic vs. open pneumonectomy
Comparison of acute phase protein and hemodynamic variables in dogs undergoing video-assisted thoracoscopic vs. open pneumonectomy
复制标题
接受电视胸腔镜与开腹肺切除术的狗的急性时相蛋白和血流动力学变量的比较
DOI：
10.3892/etm.2017.4257
复制
发表时间：
2017-05-01
影响因子：
2.7
通讯作者：
Wang, Hong-Bin
中科院分区：
文献类型：
--
作者：
Liu, Hai-Feng;Ren, Qing-Ming;Wang, Hong-Bin
已经证明，电视胸腔镜手术（VATS）在人类和动物模型中是可行和安全的。本研究的目的是比较电视胸腔镜肺切除术与标准经胸肺切除术的手术结果，以确定电视胸腔镜肺切除术的急性期反应，并分析电视胸腔镜肺切除术与标准经胸肺切除术之间的差异。共14只犬被分为两组（n= 7）;一组接受VATS，另一组接受经胸肺切除术。除了血细胞计数和血清急性时相蛋白（APP）浓度外，还监测术前、术中和术后的生理参数。分析两种入路的APP和血流动力学变化。VATS组的平均手术时间（176.7 min）明显长于开放组（132.4 min）。所有APP浓度在术后第1天显著升高，并逐渐降低至术前浓度。开放组术后第3天血清C反应蛋白浓度和第1天白色细胞计数明显高于VATS组（P< 0.05）。两组间生理参数无差异。尽管VATS花费更长时间，但动物经历了更小的切口和更小的应力。因此，我们认为，
It has been demonstrated that video-assisted thoracoscopic surgery (VATS) is feasible and safe in humans and animal models. The aim of the present study was to compare the surgical outcome using VATS with that of the standard transthoracic approach for pneumonectomy in dogs, to determine the acute-phase reaction in VATS pneumonectomy, and to analyze the difference between VATS and the standard transthoracic approach. A total of 14 dogs were divided into two groups (n= 7); one group underwent VATS and the other group underwent a transthoracic pneumonectomy. Pre-, intra- and post-operative physiologic parameters were monitored, in addition to the blood cell count and serum acute-phase protein (APP) concentrations. The APP and hemodynamic changes between the two approaches were analyzed. Mean surgical time in the VATS group (176.7 min) was significantly longer compared with the open group (132.4 min). All APP concentrations were significantly increased at day 1 postoperation and gradually decreased to preoperative concentrations. The serum concentration of C-reactive protein on day 3 and the white blood cell count on day 1 were significantly higher following surgery in the open group compared with the VATS group (P< 0.05). No differences were observed in the physiological parameters between the two groups. Although VATS took longer, animals experienced smaller incision and less stress. Therefore,