IS BILE OR ARE PANCREATICODUODENAL SECRETIONS RELATED TO GASTRIC CARCINOGENESIS IN RATS WITH REFLUX THROUGH THE PYLORUS
IS BILE OR ARE PANCREATICODUODENAL SECRETIONS RELATED TO GASTRIC CARCINOGENESIS IN RATS WITH REFLUX THROUGH THE PYLORUS
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DOI：
10.1007/bf01211798
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发表时间：
1992-09-01
影响因子：
3.6
通讯作者：
HATTORI, T
中科院分区：
文献类型：
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作者：
MIWA, K;FUJIMURA, T;HATTORI, T
雄性Wistar大鼠接受三种手术反流手术中的一种，允许部分或全部十二指肠内容物通过幽门回流到胃中，从而产生单独胆汁反流、单独胰腺-十二指肠反流和联合反流的模型。所有存活的动物在手术后50周被处死，并对胃癌的发展进行评估。16只有胰十二指肠反流的动物和32只行胃切除的对照动物均未发现肿瘤，而胆汁反流组的2/8和联合反流组的11/29出现了胃癌。与对照组相比，胆汁或复合反流动物的肿瘤发生率显著升高(P<；0.05和P<；0.01)。所有的癌都发生在幽门附近的胃窦区。腺瘤只在发生癌症的动物组中观察到，并且发生在胃的同一区域。这些结果表明，十二指肠内容物的成分是胆汁，而不是胰腺十二指肠分泌物，与胃癌的发生有关。
Male Wistar rats were subjected to one of three types of operative reflux procedure that allowed part or all of the duodenal contents to flow back into the stomach through the pylorus, thus producing models of bile reflux alone, pancreaticoduodenal reflux alone, and combined reflux. All surviving animals were killed 50 weeks after surgery and the development of gastric cancer was assessed. No cancer was seen in 16 animals with pancreaticoduodenal reflux or in 32 control animals with gastrotomy, whereas 2/8 animals with bile reflux and 11/29 animals with combined reflux had gastric carcinoma. Compared with the control group, the incidence of carcinoma in animals with bile or combined reflux was significantly higher (P < 0.05 and P < 0.01 respectively). All carcinomas developed in the antral area near the pylorus. Adenomas were observed only in the groups of animals developing carcinoma and occurred in the same region of the stomach. These results suggest that bile, and not pancreaticoduodenal secretions, is the component of the duodenal contents responsible for the development of gastric carcinoma.