Brain tumor stem cells: Molecular characteristics and their impact on therapy.
Brain tumor stem cells: Molecular characteristics and their impact on therapy.
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DOI：
10.1016/j.mam.2013.06.004
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发表时间：
2014-10
影响因子：
10.6
通讯作者：
Rich, Jeremy N.
中科院分区：
文献类型：
--
作者：
Schonberg, David L.;Lubelski, Daniel;Miller, Tyler E.;Rich, Jeremy N.
胶质母细胞瘤(GBM)是最常见的原发脑肿瘤，也是人类最致命的癌症之一，传统的治疗方法只能提供姑息治疗。在了解脑癌遗传学和通过测试新的靶向治疗对这些肿瘤进行建模方面取得了很大进展，但这些进展并未转化为患者预后的实质性改善。多种化疗药物，包括治疗胶质母细胞瘤的一线药物替莫唑胺，已经被开发出来杀死癌细胞。然而，替莫唑胺在GBM中的反应是温和的。放射治疗也是适度有效的，但由于附带辐射对健康脑组织的损害和放射抵抗的发展，这种方法受到限制。治疗耐药至少部分归因于肿瘤内具有干细胞样特征和肿瘤增殖能力的细胞群，称为癌症干细胞。在GBM中，肿瘤内的异质性来自于区域遗传变异和细胞层级的组合，通常由不同的癌症干细胞区位调节，最明显的是血管周围和缺氧区。近年来，随着肿瘤干细胞在肿瘤生物学中的重要地位的出现，肿瘤干细胞与肿瘤微环境、致癌信号通路和表观遗传修饰之间存在共生关系。肿瘤干细胞的起源及其在脑肿瘤生长和治疗耐药中的作用正在积极研究中，新的抗癌干细胞疗法为这种致命疾病提供了潜在的新希望。
Glioblastoma (GBM) is the most prevalent primary brain tumor and ranks among the most lethal of human cancers with conventional therapy offering only palliation. Great strides have been made in understanding brain cancer genetics and modeling these tumors with new targeted therapies being tested but these advances have not translated into substantially improved patient outcomes. Multiple chemotherapeutic agents, including temozolomide, the first-line treatment for glioblastoma, have been developed to kill cancer cells. However, the response to temozolomide in GBM is modest. Radiation is also moderately effective but this approach is plagued by limitations due to collateral radiation damage to healthy brain tissue and development of radioresistance. Therapeutic resistance is attributed at least in part to a cell population within the tumor that possesses stem-like characteristics and tumor propagating capabilities, referred to as cancer stem cells. Within GBM, the intratumoral heterogeneity is derived from a combination of regional genetic variance and a cellular hierarchy often regulated by distinct cancer stem cell niches, most notably perivascular and hypoxic regions. With the recent emergence as a key player in tumor biology, cancer stem cells have symbiotic relationships with the tumor microenvironment, oncogenic signaling pathways, and epigenetic modifications. The origins of cancer stem cells and their contributions to brain tumor growth and therapeutic resistance are under active investigation with novel anti-cancer stem cell therapies offering potential new hope for this lethal disease.
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影响因子：
64.5
作者：
Brunet, A;Bonni, A;Greenberg, ME
通讯作者：
Greenberg, ME
影响因子：
5.3
作者：
Abdouh, Mohamed;Facchino, Sabrina;Bernier, Gilbert
通讯作者：
Bernier, Gilbert
影响因子：
5.2
作者：
Bar, Eli E.;Chaudhry, Aneeka;Eberharta, Charles G.
通讯作者：
Eberharta, Charles G.
DOI：
10.1007/978-1-61779-340-0_9
发表时间：
2012-01-01
期刊：
ONCOLYTIC VIRUSES: METHODS AND PROTOCOLS
影响因子：
--
作者：
Alonso, Marta M.;Jiang, Hong;Fueyo, Juan
通讯作者：
Fueyo, Juan
影响因子：
50.3
作者：
Barrett, Lindy E.;Granot, Zvi;Benezra, Robert
通讯作者：
Benezra, Robert