Facile Microwave-Assisted Solid-Phase Synthesis of Highly Fluorescent Nitrogen-Sulfur-Codoped Carbon Quantum Dots for Cellular Imaging Applications.
Facile Microwave-Assisted Solid-Phase Synthesis of Highly Fluorescent Nitrogen-Sulfur-Codoped Carbon Quantum Dots for Cellular Imaging Applications.
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DOI：
10.1002/chem.201501723
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发表时间：
2015-09
期刊：
影响因子：
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通讯作者：
Yong Wang;Qianfen Zhuang;Y. Ni
中科院分区：
文献类型：
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作者：
Yong Wang;Qianfen Zhuang;Y. Ni
碳量子点（CQD）作为一类尺寸小于10 nm的新型荧光零维纳米材料，近年来在基础科学和技术应用方面受到了广泛关注。然而，报道的合成方法通常不太适合于具有高荧光量子产率（QY）的CQD的大规模生产。本文提出了一种新的微波辅助干燥一锅法合成CQD的方法，首次制备了高QY（61.3%）的CQD。CQD的产率为35±3重量%。采用TEM、AFM、XRD、XPS、FTIR、UV/维斯吸收光谱和荧光光谱等技术对所制备的CQDs进行了表征。结果表明，氮和硫的双重掺杂是量子点高量子产率的主要原因。由于其高QY、良好的水溶性、良好的生物相容性、高光稳定性和低细胞毒性，此类CQD随后被用作活细胞成像试剂。
Carbon quantum dots (CQDs) have recently attracted significant attention for both their fundamental science and technological applications as a new class of fluorescent zero-dimensional nanomaterials with a size below 10 nm. However, the reported methods of synthesis were generally less suitable for the large-scale production of the CQDs with high-fluorescent quantum yield (QY). In the paper, a novel one-pot microwave-assisted drying synthesis approach was presented to prepare CQDs with high QY of 61.3 % for the first time. The production yield of CQDs was 35±3 % in weight. The as-prepared CQDs were characterized by various techniques such as TEM, AFM, XRD, XPS, FTIR spectroscopy, UV/Vis absorption spectroscopy, and fluorescence spectroscopy. The results showed that the high QY of CQDs was largely attributed to the dual doping of nitrogen and sulphur into CQDs. Such CQDs were then used as live-cell imaging reagents due to their high QY, good water dispersibility, fine biocompatibility, high photostability, and low cytotoxicity.