Decay of coronavirus disease 2019 mRNA vaccine-induced immunity in people with HIV.
Decay of coronavirus disease 2019 mRNA vaccine-induced immunity in people with HIV.
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DOI：
10.1097/qad.0000000000003263
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发表时间：
2022-07-15
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目前的COVID-19 mRNA疫苗在PLWH中诱导强烈的SARS-CoV-2特异性体液和细胞应答。然而，在这些个体中尚未研究效应免疫应答的衰减速率。在这里，我们报告了一个显着减弱的抗体反应，但持续的T细胞反应后6个月接种病毒抑制PLWH与高CD 4 + T细胞计数。这些反应与健康供体中观察到的反应相当。
Current COVID-19 mRNA vaccines induce robust SARS-CoV-2-specific humoral and cellular responses in PLWH. However, the rate of decay of effector immune responses has not been studied in these individuals. Here we report a significant waning of antibody responses but persistent T cell responses six months post vaccination in virally suppressed PLWH with high CD4+ T cell counts. These responses are comparable to those seen in healthy donors.