Does Type of Bolus Insulin Matter in the Hospital? Retrospective Cohort Analysis of Outcomes Between Patients Receiving Analogue Versus Human Insulin
Does Type of Bolus Insulin Matter in the Hospital? Retrospective Cohort Analysis of Outcomes Between Patients Receiving Analogue Versus Human Insulin
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DOI：
10.1016/j.clinthera.2010.10.009
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发表时间：
2010-10-01
影响因子：
3.2
通讯作者：
Dubois, Robert W.
中科院分区：
文献类型：
--
作者：
Ko, Kelly J.;Tomor, Veronica;Dubois, Robert W.
背景：住院患者的血糖控制不佳与发病率和死亡率增加有关。研究表明，与人推注胰岛素相比，推注类似胰岛素可能更有效地实现血糖 (BG) 控制。 目的：本研究比较接受类似物或人推注胰岛素的住院患者的死亡率、住院时间 (LOS)、费用和 BG 控制。方法：这项回顾性队列分析使用了 Health Facts 数据库（堪萨斯州 Cerner Corporation）2004 年 1 月 1 日至 2007 年 12 月 31 日的数据。密苏里州城）。该研究包括在住院期间仅接受类似物或人推注胰岛素的非手术成年患者。使用倾向评分匹配和多变量回归分析来比较使用类似物与人推注胰岛素治疗的患者。研究结果是院内死亡率、幸存者的医院住院时间（以避免非幸存者中可能短暂住院而扭曲结果）以及住院血糖控制（存在与不存在），定义为平均 BG 为 70 至
Background: Poor glycemic control in hospitalized patients has been associated with increased morbidity and mortality. Research suggests that analogue bolus insulin may be more effective in achieving blood glucose (BG) control compared with human bolus insulin.Objective: This study compares mortality, length of stay (LOS), costs, and BG control in hospitalized patients receiving either analogue or human bolus insulin.Methods: This retrospective cohort analysis used data from January 1, 2004, to December 31, 2007, within the Health Facts database (Cerner Corporation, Kansas City, Missouri). Nonsurgical adult patients who received exclusively analogue or human bolus insulin during hospitalization were included in the study. Propensity score matching and multivariate regression analyses were used to compare patients treated with analogue versus human bolus insulin. The study outcomes were in-hospital mortality, hospital LOS among survivors (to avoid potentially short hospitalizations among nonsurvivors distorting results), and hospitalized BG control (present vs absent), defined as having a mean BG of 70 to