Sortilin regulates keratinocyte proliferation and apoptosis through the PI3K-AKT signaling pathway
Sortilin regulates keratinocyte proliferation and apoptosis through the PI3K-AKT signaling pathway
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Sortilin 通过 PI3K-AKT 信号通路调节角质形成细胞增殖和凋亡
DOI：
10.1016/j.lfs.2021.119630
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发表时间：
2021-05-19
期刊：
影响因子：
6.1
通讯作者：
Leng, Hong
中科院分区：
文献类型：
--
作者：
Zhang, Rui;Wang, Ye Hua;Leng, Hong
Sortilin可调节不同细胞的增殖和死亡，但其在角化细胞增殖和凋亡中的作用尚不清楚。本研究发现银屑病患者sortilin水平显著升高，抑制sortilin可消除M5鸡尾酒溶液诱导的HaCaT细胞增殖，提高cleaved caspase 3蛋白水平和Bax/Bcl-2比值；然而，p-PI3K和p-AKT水平降低。此外，sortilin沉默缓解了与牛皮癣样皮肤病变相关的特征性变化。综上所述，抑制sortilin表达可通过灭活PI3K/AKT信号通路抑制HaCaT细胞中角质形成细胞的增殖，为银屑病的治疗提供了新的靶点。
Sortilin is found to regulate proliferation and death of different cells, while its role in regulating keratinocyte proliferation and apoptosis is still unknown. In this study, we found that sortilin levels significantly increased in psoriasis patients, and sortilin suppression eliminated the proliferation of HaCaT cells induced by M5 cocktail solution and enhanced the levels of cleaved caspase 3 protein and the Bax/Bcl-2 ratio; however, levels of p-PI3K and p-AKT were decreased. In addition, sortilin silencing remitted the characteristic changes associated with psoriasis-like skin lesions. In summary, suppressed sortilin expression helped inhibit keratinocyte proliferation in HaCaT cells by inactivating PI3K/AKT signaling, which provides a new target for the therapy of psoriasis.