Number of children and risk of metabolic syndrome in women
Number of children and risk of metabolic syndrome in women
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DOI：
10.1089/jwh.2006.15.763
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发表时间：
2006-07-01
影响因子：
3.5
通讯作者：
Bastian, Lori A.
中科院分区：
文献类型：
--
作者：
Cohen, Adi;Pieper, Carl F.;Bastian, Lori A.
背景资料：在美国，代谢综合征的患病率很高，如国家胆固醇教育计划专家小组关于成人高血胆固醇检测、评估和治疗的第三次报告（ATP III）所定义。生育因素与妇女代谢综合征之间的关系尚不清楚。方法：我们研究了妇女生育子女数和母乳喂养史与代谢综合征风险之间的关系。我们使用了第三次全国健康和营养检查调查（NHANES III）的全国代表性数据。共有4699名（年龄>= 20岁）非妊娠妇女纳入本报告。代谢综合征的定义根据ATP III。结果：总体而言，22.6%的妇女被确定为有代谢综合征。随着儿童数量的增加，代谢综合征的发生率显著升高，表现出剂量反应关系（p < 0.0001）。在控制了年龄、种族、收入、教育和其他社会人口、生殖和行为风险因素后，每增加一个孩子，代谢综合征的几率增加13%（95%CI，6%-20%）。在对经产妇女进行的类似对照分析中，有母乳喂养史> 1个月的妇女患代谢综合征的几率降低22%（95%CI，1%-39%）。然而，这两种影响不再显着纳入后的身体质量指数（BMI）categoris.Conclusions：在全国样本的妇女，越来越多的儿童与代谢综合征的发病率较高，母乳喂养的历史与代谢综合征的发病率下降。这些关系的强度在额外调整BMI后降低，表明体重或体重变化可能是产次和母乳喂养对代谢综合征风险影响的重要介导因素。
Background: In the United States, there is a high prevalence of metabolic syndrome, as defined by The Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III). The relationship between reproductive factors and metabolic syndrome in women is unknown.Methods: We examined the association of number of children and breastfeeding history with metabolic syndrome risk among women. We used nationally representative data from the Third National Health and Nutrition Examination Survey ( NHANES III). A total of 4699 ( age >= 20) nonpregnant women were included in this report. Metabolic syndrome was defined according to ATP III.Results: Overall, 22.6% of women were determined to have metabolic syndrome. The rate of metabolic syndrome was significantly higher with increasing numbers of children, demonstrating a dose-response relationship ( p < 0.0001). After controlling for age, race/ethnicity, income, education, and other sociodemographic, reproductive, and behavioral risk factors, the odds of metabolic syndrome increased 13% (95% CI, 6%-20%) with each additional child. In a similarly controlled analysis in parous women, the odds of metabolic syndrome decreased 22% ( 95% CI, 1%-39%) in women with a history of breastfeeding for > 1 month. However, both effects were no longer significant after inclusion of body mass index (BMI) categories.Conclusions: In a national sample of women, increasing number of children was associated with higher rates of metabolic syndrome, and history of breastfeeding was associated with decreased rates of metabolic syndrome. The strength of these relationships was decreased after additional adjustment for BMI, suggesting that weight or weight changes may be an important mediator of the effects of parity and breastfeeding on the risk of metabolic syndrome.