Synthesis of C3-functionalized indole derivatives via Bronsted acid-catalyzed regioselective arylation of 2-indolylmethanols with guaiazulene
Synthesis of C3-functionalized indole derivatives via Bronsted acid-catalyzed regioselective arylation of 2-indolylmethanols with guaiazulene
复制标题
通过布朗斯台德酸催化 2-吲哚甲醇与愈创蓝油烯的区域选择性芳基化合成 C3 功能化吲哚衍生物
DOI：
10.1039/d1ob02384e
复制
发表时间：
2022-01-21
影响因子：
3.2
通讯作者：
Fu, Jie
中科院分区：
文献类型：
--
作者：
Liu, Yang;Cao, Meng;Fu, Jie
A Bronsted acid catalyzed method for the construction of guaiazulenyl C3-functionalized indole derivatives is reported for the first time. The reactions proceeded smoothly at ambient temperature by using (+/-)-10-camphorsulfonic acid (CSA) as a catalyst, 2-indolylmethanols and guaiazulene as substrates, and the desired products were obtained in high yields with excellent regioselectivities.
