The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride
The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride
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DOI：
10.1002/syn.20066
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发表时间：
2004-11-01
期刊：
影响因子：
2.3
通讯作者：
Dagher, A
中科院分区：
文献类型：
--
作者：
Barrett, SP;Boileau, I;Dagher, A
正电子发射断层扫描和[C-11]雷氯必利被用来评估10名吸烟者对吸烟的多巴胺能反应。尼古丁剥夺的吸烟者在不同的日子扫描两次。在一种情况下，参与者在扫描仪中吸烟，而在另一种情况下，他们保持尼古丁戒断。每一天，受试者都监测他们体验的享乐属性以及他们的渴望程度。初步分析显示，尾状核、壳核或腹侧纹状体中[C-11]雷氯必利结合电位（BP）的条件之间无显著差异。由于先前的研究表明，药物诱导的多巴胺传递与渴望和/或享乐药物效应的水平有关，因此检查了这些变量与[C-11]雷氯必利BP之间的关系。吸烟降低了渴望水平，但与血压变化没有系统性相关。然而，在尾状核（P < 0.001）和后壳核（P < 0.05），对吸烟的享乐反应与血压降低相关，而在腹侧纹状体则不相关。事后分析显示，只有五个十吸烟者报告情绪提升的影响，在响应吸烟程序。在这些受试者中，吸烟与尾状核[C-11]雷氯必利BP降低相关。另一方面，在报告对吸烟的情绪反应减弱的受试者中，尾状核和壳核的血压升高。这些结果表明，愉快的药物经验与增加多巴胺传输在背侧纹状体，而不愉快的经验可能与减少多巴胺释放在这个地区。
Positron emission tomography and [C-11]raclopride were used to assess the dopaminergic response to cigarette smoking in ten smokers. Nicotine-deprived smokers were scanned twice on separate days. In one condition, participants smoked their usual brand of cigarettes while in the scanner and in the other condition they remained nicotine abstinent. On each day, subjects monitored the hedonic properties of their experience as well as their levels of craving. Initial analyses revealed no significant differences between the conditions in [C-11]raclopride binding potential (BP) in the caudate, putamen, or ventral striatum. Because previous research suggested that drug-induced dopamine transmission is related to levels of craving and/or hedonic drug effects, the relationship between these variables and [C-11]raclopride BP was examined. Craving levels were reduced by smoking but were not systematically related to BP change. However, the hedonic response to smoking was correlated with BP reduction in the caudate (P < 0.001) and posterior putamen (P < 0.05) but not in the ventral striatum. Post hoc analyses revealed that only five of the ten smokers reported mood-elevating effects in response to the smoking procedure. In these subjects, smoking was associated with decreased [C-11]raclopride BP in the caudate. On the other hand, among subjects that reported a diminished mood response to smoking there was an increase in BP in the caudate and putamen. These results suggest that pleasurable drug experiences are associated with increased dopamine transmission in the dorsal striatum while unpleasant experiences may be related to decreased dopamine release in this region.