From factors to mechanisms: translation and translational control in eukaryotes
From factors to mechanisms: translation and translational control in eukaryotes
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DOI：
10.1016/s0959-437x(99)00005-2
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发表时间：
1999-10-01
影响因子：
4
通讯作者：
Hentze, MW
中科院分区：
文献类型：
--
作者：
Preiss, T;Hentze, MW
生物化学和遗传学研究揭示了真核生物翻译起始因子之间的相互作用网络，进一步完善或重新定义了它们的功能。翻译的mRNA作为一个“闭环”的概念已经从两个mRNA末端及其相关因子之间的物理和功能相互作用的鉴定中获得了支持。翻译控制机制开始解开足够的细节，以查明在启动途径中受影响的步骤。
Biochemical and genetic studies are revealing a network of interactions between eukaryotic translation initiation factors, further refining or redefining perceptions of their function. The notion of translated mRNA as a 'closed-loop' has gained support from the identification of physical and functional interactions between the two mRNA ends and their associated factors. Translational control mechanisms are beginning to unravel in sufficient detail to pinpoint the affected step in the initiation pathway.