Knocking out the DREAM to study pain.
Knocking out the DREAM to study pain.
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打破研究疼痛的梦想。
DOI：
10.1056/nejmcibr021152
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Vogt,BrentA
中科院分区：
文献类型：
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作者：
Vogt,BrentA
虽然已知一些急性疼痛演变为慢性综合征的机制，但许多其他机制，包括脑干、丘脑和大脑皮层的变化，尚不清楚。此外，尽管阿片类化合物可以在一定程度上缓解慢性神经病理性和炎症性疼痛，但对这些症状仍然知之甚少。对有中心原因的疼痛的治疗选择甚至更加黯淡。然而，现在，基因组工程的革命为研究急、慢性疼痛的机制和设计新的、更具选择性的药物开辟了新的可能性。前强啡肽是强啡肽的前身。
Although some mechanisms by which acute pain evolves into a chronic syndrome are known, many others, including changes in the brain stem, thalamus, and cerebral cortex, are not understood. Moreover, even though chronic neuropathic and inflammatory pain can be relieved to some extent with opiate compounds, these syndromes are still poorly understood. The treatment options for pain with a central cause are even more bleak. Now, however, the revolution in genomic engineering has opened up new possibilities for studying the mechanisms of acute and chronic pain and designing novel and more selective drugs.Prodynorphin is the precursor of dynorphin, an . . .