EXTINCTION OF FEAR .1. EFFECTS OF AMYLOBARBITONE AND DEXAMPHETAMINE GIVEN SEPARATELY AND IN COMBINATION ON FEAR AND EXPLORATORY BEHAVIOUR IN RATS
EXTINCTION OF FEAR .1. EFFECTS OF AMYLOBARBITONE AND DEXAMPHETAMINE GIVEN SEPARATELY AND IN COMBINATION ON FEAR AND EXPLORATORY BEHAVIOUR IN RATS
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DOI：
10.1007/bf00402640
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发表时间：
1971-01-01
期刊：
影响因子：
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通讯作者：
KUMAR, R
中科院分区：
文献类型：
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作者：
KUMAR, R
老鼠对先前与不可避免的电击有关的环境的被动回避被视为重复的未受惩罚的测试中恐惧水平的指数。在这些测试中还记录了运动和非运动探索活动。虽然淀粉巴比妥减少了恐惧，但它并没有加速恐惧的消退;在休克和未休克的大鼠中，运动量都增加了，对淀粉巴比妥的这些作用没有产生耐受性;右旋非他明延缓了消退，结果是即使在停止给药时，恐惧水平仍然很高。在保持恐惧水平的同时，右旋安非他明也增加了运动活动，但这仅限于“安全”的区域的apparent.Mixtures的淀粉巴比妥和右旋安非他明产生更大的增加运动活动比单独的药物，其影响的恐惧是中间的。在这两种情况下，组成药物的作用之间的相互作用似乎都是相加的。右旋苯丙胺对恐惧消退的抑制作用并没有通过添加淀粉巴比妥而改变。
Passive avoidance by rats of an environment previously associated with inescapable electric shocks, was taken as an index of the level of fear on repeated, unpunished tests. Locomotor and non-locomotor exploratory activity was also recorded during these tests. Although amylobarbitone diminished fear it did not accelerate its extinction; the amounts of locomotion were increased in both shocked and unshocked rats and tolerance did not develop to these effects of amylobarbitone.Dexamphetamine retarded extinction, with the result that the level of fear remained high even when the drug was withheld. At the same time as maintaining the level of fear dexamphetamine also increased locomotor activity, but this was confined to “safe” areas of the apparatus.Mixtures of amylobarbitone and dexamphetamine produced greater increases in locomotor activity than did the separate drugs, and their effects on fear were intermediate. In both cases the interactions between the effects of the constituent drugs did not appear to be other than additive. The inhibitory effects of dexamphetamine on the extinction of fear were not modified by adding amylobarbitone.