Trends in the incidence of invasive and in situ vulvar carcinoma
Trends in the incidence of invasive and in situ vulvar carcinoma
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DOI：
10.1097/01.aog.0000210268.57527.a1
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发表时间：
2006-05-01
影响因子：
7.2
通讯作者：
Virnig, Beth A.
中科院分区：
文献类型：
--
作者：
Judson, Patricia L.;Habermann, Elizabeth B.;Virnig, Beth A.
目的：为了描述外阴原位癌和外阴癌随时间推移的发病率，我们使用了监测流行病学和最终结果数据库来评估外阴癌发病率在28年期间（1973年至2000年）的趋势，并确定是否有随着时间的推移发生了变化。收集的信息包括患者特征、原发肿瘤部位、肿瘤分级和生命状态随访。我们计算了发病率的10年的年龄，使用卡方检验比较人口统计学特征，并测试了发病率随时间的变化趋势。结果：共有13,176原位和浸润性外阴癌被确定; 57%的妇女被诊断为原位，44%的浸润性疾病。外阴原位癌从1973年到2000年增加了411%。在同一时期，侵袭性外阴癌增加了20%。外阴原位癌和侵袭性癌的发病率在不同年龄组中分布不同。外阴原位癌发病率在40-49岁之间呈上升趋势，然后逐渐下降，而浸润性外阴癌的发病率随着年龄的增长而增加，50岁以后发病率上升更快。结论：外阴原位癌发病率呈上升趋势。侵袭性外阴癌的发病率也在增加，但速度要低得多。
OBJECTIVE: To characterize the incidence of vulvar carcinoma in situ and vulvar cancer over time.METHODS: We used the Surveillance Epidemiology and End Results database to assess trends in the incidence of vulvar cancer over a 28-year period (1973 through 2000) and determined whether there had been a change in incidence over time. Information collected included patient characteristics, primary tumor site, tumor grade, and follow-up for vital status. We calculated the incidence rates by decade of age, used chi(2) tests to compare demographic characteristics, and tested for trends in incidence over time.RESULTS: A total of 13,176 in situ and invasive vulvar carcinomas were identified; 57% of the women were diagnosed with in situ, 44% with invasive disease. Vulvar carcinoma in situ increased 411% from 1973 to 2000. Invasive vulvar cancer increased 20% during the same period. The incidence rates for in situ and invasive vulvar carcinomas are distributed differently across the age groups. In situ carcinoma incidence increases until the age of 40-49 years and then decreases, whereas invasive vulvar cancer risk increases as a woman ages, increasing more quickly after 50 years of age.CONCLUSION: The incidence of in situ vulvar carcinoma is increasing. The incidence of invasive vulvar cancer is also increasing but at a much lower rate.