Genetic characterization of early isolates of Japanese encephalitis virus: genotype II has been circulating since at least 1951
Genetic characterization of early isolates of Japanese encephalitis virus: genotype II has been circulating since at least 1951
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DOI：
10.1099/vir.0.013631-0
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发表时间：
2010-01-01
影响因子：
3.8
通讯作者：
Barrett, Alan D. T.
中科院分区：
文献类型：
--
作者：
Schuh, Amy J.;Li, Li;Barrett, Alan D. T.
日本脑炎病毒（JEV）由五种基因型（GI-V）组成。1930- 1970年代期间从“苏联”、日本和韩国分离的16株JEV毒株的系统发育特征显示，15株属于GIII，证实了GIII是1935年（分离出原型毒株; GIII病毒）和1990年代（当GI取代GIII时）之间日本和韩国JEV的主要基因型。其中一个韩国分离株属于GII，表明GII的传播时间比以前认为的至少长19年。以前，GII与地方病有关，这种基因型从未在泰国南部北部分离出来。此外，GIII流行的北方边界从日本延伸到“苏联”。
Japanese encephalitis virus (JEV) consists of five genotypes (GI-V). Phylogenetic characterization of 16 JEV strains isolated from the 'USSR', Japan and Korea during the 1930-1970s revealed that 15 strains fell into GIII, confirming that GIII was the predominant genotype of JEV in Japan and Korea between 1935 (isolation of the prototype strain; a GIII virus) and the 1990s (when GI supplanted GIII). One of the Korean isolates fell into GII, demonstrating that GII has been circulating for at least 19 years longer than previously thought. Formerly, GII was associated with endemic disease and this genotype had never been isolated north of Southern Thailand. Additionally, the northern border of GIII prevalence was extended from Japan to the 'USSR'.