Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment.
Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment.
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DOI：
10.1177/1759091418777438
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发表时间：
2018-01
期刊：
影响因子：
4.7
通讯作者：
Jia JJ
中科院分区：
文献类型：
--
作者：
Zeng XS;Geng WS;Jia JJ
Parkinson disease (PD) is the second most common neurodegenerative movement disorder. Pharmacological animal models are invaluable tools to study the pathological mechanisms of PD. Currently, invertebrate and vertebrate animal models have been developed by using several main neurotoxins, such as 6-hydroxydopamine, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, paraquat, and rotenone. These models achieve to some extent to reproduce the key features of PD, including motor defects, progressive loss of dopaminergic neurons in substantia nigra pars compacta, and the formation of Lewy bodies. In this review, we will highlight the pathogenic mechanisms of those neurotoxins and summarize different neurotoxic animal models with the hope to help researchers choose among them accurately and to promote the development of modeling PD.
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