Non-reporting and inconsistent reporting of race and ethnicity in articles that claim associations among genotype, outcome, and race or ethnicity
Non-reporting and inconsistent reporting of race and ethnicity in articles that claim associations among genotype, outcome, and race or ethnicity
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DOI：
10.1136/jme.2005.014456
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发表时间：
2006-12-01
影响因子：
4.1
通讯作者：
Cook-Deegan, R.
中科院分区：
文献类型：
--
作者：
Shanawani, H.;Dame, L.;Cook-Deegan, R.
背景资料：在医学研究中使用种族作为一个类别是激烈辩论的焦点，由于分析所依赖的假定自变量、种族和族裔的不一致，情况变得更加复杂。由于确定参与者种族或民族的方法不一致，因此难以进行解释。在已发表的文献中，未能详细说明如何确定种族或民族是常见的。假设：他们将研究参与者分配到种族或民族类别的标准没有被已发表的文章报道。方法：在268份已发表的报告中，对分配研究参与者的种族和民族的方法进行了回顾，报告了种族之间的关联。结果：在268篇已发表的回顾性报告中，有192篇（72%）没有解释他们将种族或民族作为自变量的方法。这是尽管事实上，180（67%）的这些报告得出的结论之间的关联遗传，健康结果和种族或ethnication.Conclusions：需要更多的关注，以种族和民族的定义在遗传学研究，特别是在这些疾病的健康差距是已知存在的。
Background: The use of race as a category in medical research is the focus of an intense debate, complicated by the inconsistency of presumed independent variables, race and ethnicity, on which analysis depends. Interpretation is made difficult by inconsistent methods for determining the race or ethnicity of a participant. The failure to specify how race or ethnicity was determined is common in the published literature.Hypothesis: Criteria by which they assign a research participant to racial or ethnic categories are not reported by published articles.Methods: Methods were reviewed for assigning race and ethnicity of research participants in 268 published reports reporting associations among race (or ethnicity), health outcome and genotype.Results: Of the 268 published reports reviewed, it was found that 192 (72%) did not explain their methods for assigning race or ethnicity as an independent variable. This was despite the fact that 180 (67%) of those reports reached conclusions about associations among genetics, health outcome and race or ethnicity.Conclusions: More attention needs to be given to the definition of race and ethnicity in genetic studies, especially in those diseases where health disparities are known to exist.